ID L2G9R1_COLFN Unreviewed; 493 AA.
AC L2G9R1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase isomerase family {ECO:0000313|EMBL:ELA35342.1};
DE SubName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating {ECO:0000313|EMBL:KAF4477355.1};
GN Name=NSDHL {ECO:0000313|EMBL:KAF4477355.1};
GN ORFNames=CGGC5_4916 {ECO:0000313|EMBL:ELA35342.1}, CGGC5_v013587
GN {ECO:0000313|EMBL:KAF4477355.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA35342.1};
RN [1] {ECO:0000313|EMBL:ELA35342.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA35342.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF4477355.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4477355.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4477355.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4477355.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P., Shirasu K.;
RT "Genome sequencing and assembly of multiple isolates from the
RT Colletotrichum gloeosporioides species complex.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KB020574; ELA35342.1; -; Genomic_DNA.
DR EMBL; ANPB02000008; KAF4477355.1; -; Genomic_DNA.
DR RefSeq; XP_007275628.1; XM_007275566.1.
DR AlphaFoldDB; L2G9R1; -.
DR STRING; 1213859.L2G9R1; -.
DR EnsemblFungi; ELA35342; ELA35342; CGGC5_4916.
DR HOGENOM; CLU_045580_1_0_1; -.
DR InParanoid; L2G9R1; -.
DR OrthoDB; 1649721at2759; -.
DR Proteomes; UP000011096; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:ELA35342.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011096}.
FT DOMAIN 75..363
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 493 AA; 54532 MW; 8A6C00CC9561E0DF CRC64;
MLESWTAKLV FGLVAAAVLY LWRINWAMSN TPPEAQRVSP DRWTPDRIKR VFERMEKQPI
DWTPHLPPKL DRRYVIVGGA GLVGGQLAIQ LIARGHPPEA IRIIDFRKPL RDDMSEGPVS
QVDFAQADIS SESATSAAFA KPWPESVAQL PLTVFHTAAV IRPSERSPMV YDRCSRVNTT
GAAHVLAAAK ASGAGVFIFT SSCSVALKPV NFFNSPFKQW PANFVQVLNE LDFWKPLRPH
GEFFANYARS KAEAERLICG ANDIPEDPLQ DGGFRTGAIR PGNVIYGHKD DYLIGTTLRM
ASFPTFTAPF VQNWVHGANV ALAHLQYEAA LLGPHAHKVA ARPFLVTDGG APPTFEDFYT
LIRSVSVTPF HVQYPPPVLL LLLAHCIEAY CLLLWHVPVL QKIFSEPSMP LYMMQPASIA
GSVTALINDA DARRRVEDGG LGYQAKCTSM EGQCMQLVAW NRWVRSGGEE VRNEKGLVKD
TLEVGLEPVA RRA
//
