ID L2GBM7_COLFN Unreviewed; 2319 AA.
AC L2GBM7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Pksn polyketide synthase for alternapyrone biosynthesis {ECO:0000313|EMBL:ELA36002.1};
GN ORFNames=CGGC5_4358 {ECO:0000313|EMBL:ELA36002.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA36002.1};
RN [1] {ECO:0000313|EMBL:ELA36002.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA36002.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB020535; ELA36002.1; -; Genomic_DNA.
DR RefSeq; XP_007274880.1; XM_007274818.1.
DR STRING; 1213859.L2GBM7; -.
DR EnsemblFungi; ELA36002; ELA36002; CGGC5_4358.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OrthoDB; 2440513at2759; -.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..211
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2232..2309
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2319 AA; 254441 MW; F03FD511385F216B CRC64;
MVSPDGISHS FDSSANGYGR GEGMAGVVVK RLSTAIADGD VIRAVIRATG VNSDGKTPGI
TVPSEEAQAD LIREVYERSG LDMAQTSYFE AHGTGTPKGD PIEIRAIGST IGAARRASGM
GRLDVGSVKP NIGHTEGCAG LAGLIKTVLC LEAGLIPPIA GLQQINPEIA AENHLINFPM
ATKSWPGSGL RRASVNSFGF GGANAHLVLD DARSYLKEMR IKGRHITKKA GYRNQDSTDQ
SFDTSENMRQ LLFAISSFDR QGLGRTAQSL GEFLSQKKPV QFESLAHTLN VRRTSHLFRS
FVTAKSQEEL VSTLLSVNKE KAQPLKIRSS RSRRLVFLFT GQGAQRPGMA KELVRECPTF
RNSIATSQTY LSNLGCRWDL IDLLKNGDAE TISDPEFSQP MCTAVQIALV HVLWYWGVTA
AAVVGHSSGE MVAAYAAGAV SHEEAMRVAY YRGLLSTQVS RRLGRPGAML AVGLSEKSCR
EFLQRHDFAN TVTVACINSP QGVTLSGDAQ SISRVEASLK DAGHFARLLR TGGVAYHSPD
MQIVGEDFLK ALGPLKLRHR PLSVAMFSSV TESLILDAAE LNANYWYTNM TSSVRFSGAL
HNLLLHEGQD GLSPSIHNTT VLEIGPSKTL AGPVGQIMAA AFDSKITTGL SYLSILSAGE
DSRDTSLAAA GMLWAMGQAV DLDKVNNLSS RCDKLKLNEL PILPSYPWNH SRSYWHKTSP
NSTALGALTV PRADLLGVPT APQNPFEPSW QNVLRQDELP WLEDHAVMGA VLFPAAGYLV
IAMEALRTLA RKKNYPLYGV ELLDVQFETG LTLEDHESAL ESTNRGQGIR LTLKPRAMDE
WEYDFTIYAT SSSPEEWRRL VRGTVVGIRN TNVLRQKEDD FETSSRKVEW HSVKRPQLLE
VQRSSIDVVD PANFYTNLSA IGLKYGPTFQ GLNVIRCTPA TTACRVGKAY GELMVPDTQS
TMPGAYECEY LIHPATLDGI FQLVFAALKA ICPGGMKDAA VPVSLRRAFI ASSMPRNVHS
KLIGVADAEY DGDAKASQSA PREIIGSLVF SDGTLEEPAV MIDGIVLREL PVGSGYEAVM
DSKSDARENR IERTAQFLWK EDIDQDFDLW KDLILSKTTR LDRCSFFLDR FYHKRPNANA
VCIGSTELHE RLLQPAVNYS GTRRTHPLNR CTLVTSLEKW SAVIGVSSSS TLENPTTEKF
DLILLDENML AEEDLHDDPQ RSSDWFFKTL SKGCAAGAWF VLLGGDEKSV LPMSQIMSGV
GTRSKIKGIR ISEASVDIYC IGDELVSIHP RIKALQEQAL QADDVVKEGF RHTDIIILEQ
DYSRNTRAAC NITAPLLNRL ASTGFRISRA TLRQAIALRD QFKDKMIISL LELGQPFVYD
WGHQDFADFQ QLVDSASHIL WLTTGGLLCP YSERSLLYSP TVGLLRALRA EYPQLVLVHL
DVSEATCSDT PEAIVEVISE TLRLSRVSEE TSYSLETHFE IYESEYIEQS GCLLIPRIMA
HTEADNYVLS ETSSQDGNPL LPTFRGSFNH LESVRLQSPH LWSQTIAESR LGYWVLPERA
TENTRENSPL MGLQKRTSAI IRASHFTVKP GTCPRLQMEN GFEVPMAFHT LGVITGLNEV
HSSRTDYRTG DWVLNTTPQP IQPESMHDVR KLVKLPKSVA KAPAAAAYWL GPISTAYQVL
SVIGSVSQGD YVVIDVGESQ TLERAFAMVA HHLRARKALI IGRGRLTEQV DKDAHSDGPE
DVIISRISCL NRATIRYLQS LANGVKAVVS TTRTKETLDM LISTLSSDGC LIQLDPRGQE
DCLDNRCPKS SQIFKFDLQL WDHSASEEYR MAISRVSTWV ETGTLTLPDA LRQASTSNAN
DLAMIFESTT HGTEQEDAKI AVSLGHSDEV LMHRKMPASP PGKIDNATML DSNATYIISG
GLGSLGLHMA NMLYELGARH LMLLSRSGKA NSSDIMAALM NLERNGCNVD VVACDITSME
DMKRLGSKFS EESRPRLKGI IQSAMVLADS TFANMTFENW QKATAPKIQG SWNLHNLQRF
MTEGSSSSEN DVEDLDFFIL LSSVSGVIGN SAQGNYCAGN TFEDVLAHHR RANGMAAVSL
NIGLVSDSNH FGTGTMSSFK NIDEYLRVFG HLAPVVVSTA EVLASVKMAI AASNKQNTAL
TSCPLQIPPQ LVVGISSRIR RSRELLNYWS LDRKFDHRAA WGDDAGWEGD LAPKASLLRA
NEALPLAQDL SSGRLVVEDL LKAKLAQAMT LDVEGVDEEK SLGSYGIDSL KATEMRNWIN
REFHVDLSIF EILAPTPIAK LAMRILKACD LVNHDALGS
//
