ID   L2GPC2_VITCO            Unreviewed;      1011 AA.
AC   L2GPC2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=VICG_00463 {ECO:0000313|EMBL:ELA42365.1};
OS   Vittaforma corneae (strain ATCC 50505) (Microsporidian parasite) (Nosema
OS   corneum).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae;
OC   Vittaforma.
OX   NCBI_TaxID=993615 {ECO:0000313|EMBL:ELA42365.1, ECO:0000313|Proteomes:UP000011082};
RN   [1] {ECO:0000313|Proteomes:UP000011082}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50505 {ECO:0000313|Proteomes:UP000011082};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Didier E., Bowers L., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Vittaforma corneae strain ATCC 50505.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   EMBL; JH370132; ELA42365.1; -; Genomic_DNA.
DR   RefSeq; XP_007603916.1; XM_007603854.1.
DR   AlphaFoldDB; L2GPC2; -.
DR   STRING; 993615.L2GPC2; -.
DR   GeneID; 19881181; -.
DR   VEuPathDB; MicrosporidiaDB:VICG_00463; -.
DR   HOGENOM; CLU_011906_0_0_1; -.
DR   InParanoid; L2GPC2; -.
DR   OMA; ASNIMFI; -.
DR   OrthoDB; 169519at2759; -.
DR   Proteomes; UP000011082; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011082};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          34..100
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1011 AA;  118214 MW;  17786199EEBDB1C1 CRC64;
     MDKILDLNAE FDIKLFDEIV SSALNPSSPN KAIAENILLQ FKDLPSSWTK IDCILKNSSS
     KQSQFIALQI LEETVKSKWV LFNEEMKAGL RRYVFSTVIE RSALPSDIIL QKFNSVLIEI
     VKKDWPKRWP TFISDLIATS QSTSMQVSMN SLVILKNINE QLFIVGDEIA TTKKRLLRKT
     LKQEYYTIFH FISLILEYSE TRELDDALLE SCLGAFKSFC KSMPLEFVFS TRIVDFILGH
     LNSPHSIATL ECLLEIIELR RTYKENGMLE PSPEVLEHEK QKIALIHTEL LNFFKLYLGK
     FESYGEVSKL HLAFKKINEQ EKMFVKKYAT VFSSLYSIWI YELSLEQIKQ GLGYLVQLTK
     IEDTSIYNEI FPFWTKFIYE MYSEYPLRIP TSKPLRRNSF IFILEAMLPV FTNNMPRPEE
     VFILVNDLGE IIRDKKVETS EIEFYKKMRS NMFYLSFCIE DFMIDFFVKK IERFISTSDF
     DHVWLNKICW AIGSISNALE ESVERDFFVS IIKNLLTMCE LRNSKDEKAI IASNIMFIIG
     QYYRFLKYHN DFLTVVVKKL FEFMEEKYQG IKEMACDNFF KICEKCPNQF FLKKDKAYFY
     EEILNDLPSI TSNLDYYLQR MVIEGLLIVL KHSQKKDAKY VEMIYGTLTN QAMLDERYIT
     SIHTVIHEQS QLKMIVHLVE SYSLGFKITP EIFQNINVLN SFLYLYKHVS KPEVAFNSLV
     QKNIQILKTS LANFFETVIS SGFVYTDFVN NLCENVLLDF KSNFDPAILS LAISIVSNTK
     NHEHLIEIQR LQFFINNLIA PAVPYVVKAD EHIELSKKYL SLLNEMADKS FKIVFPIFTE
     SPAYESIVNS VLFSLTGLRE VSVLALTTLK VFFKHSLENK MFGFFNRFYL ICLENVLGLI
     FDKDMRQNYD VQVELLYDLI SYLNKIPSLN SSNNNYAIVR EFATSLFSKN FRNLTENSVK
     IFIEGILEIK NFQFFKDHLD DFNVKIYEYG DDEDIQDELD LLKERVAAGI N
//