ID   L2GRB0_VAVCU            Unreviewed;       735 AA.
AC   L2GRB0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN   ORFNames=VCUG_02338 {ECO:0000313|EMBL:ELA46169.1};
OS   Vavraia culicis (isolate floridensis) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC   Vavraia.
OX   NCBI_TaxID=948595 {ECO:0000313|EMBL:ELA46169.1, ECO:0000313|Proteomes:UP000011081};
RN   [1] {ECO:0000313|Proteomes:UP000011081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=floridensis {ECO:0000313|Proteomes:UP000011081};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Becnel J., Sanscrainte N., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Vavraia culicis strain floridensis.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL877459; ELA46169.1; -; Genomic_DNA.
DR   RefSeq; XP_008075347.1; XM_008077156.1.
DR   AlphaFoldDB; L2GRB0; -.
DR   STRING; 948595.L2GRB0; -.
DR   GeneID; 19880201; -.
DR   VEuPathDB; MicrosporidiaDB:VCUG_02338; -.
DR   HOGENOM; CLU_002472_10_1_1; -.
DR   InParanoid; L2GRB0; -.
DR   OMA; IKENCTE; -.
DR   OrthoDB; 168255at2759; -.
DR   Proteomes; UP000011081; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 2.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011081}.
FT   DOMAIN          633..649
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
SQ   SEQUENCE   735 AA;  83665 MW;  4DC7ED8ED53A8044 CRC64;
     MPSNSSSNET VEREIRNLIQ GTELGKNETA ANTANIAASS MISKENPNAG TEDMCIKLYL
     KNGMYTCTNI SIIKSHGKAF PKALGEQLIR ELLSTHAVEE YVERDGKVVL NRKGSPGNWG
     SFSDIMVSDM PISKFGCIVL TKNNVDFRFY DNMNNMISRA VYVDDDIFSM TYTIISKESI
     REVIYTNSEL ERPLVTMGVK AIRVSGKDLN LVRYLNLAEV KEVNYSNSNL NLDNNLYEEL
     NLNEMLKLFD FRTTQGRRYF STNIRGPSRD ICEIQRRQQV LFFFRNNNIN REFPDLLRIV
     KKIERGKISV GEIIALCQVL EKKDSLLRDL VNTAKKCAER NIDIIKEDII YPLQMLDFTF
     ATKEIREKID FASEKVKCFN DTMNELQLKG EEIIKSKKDE VQRISGILKN NFKEENFCIK
     IRRGDYSENM FRKNNFLEKS VLKSGVIFQT RTLNNLEREF ECLRDLERKE EKIVINNLIV
     LLKDSLNSLS AFNTLIALVD YYCGLSDKLN DEEWCVPCVY DGESNETKAN SHRFMAQDAF
     HPLVNNCIKN DISVSFTILT GPNTAGKSTF LKTIALTVIL GQMGSLVPAR NVKFELRDGI
     YIRSGASDRY GISTFMREMK DMARITNMCT QKSLILIDEL GRGTSYIDGI SLSIAIKEYL
     QTKNALAVFA THFTGKNEKM FLEGQNIELL CSEVVDGIIT YKIRSGIADS LGIEVAKKVG
     FPQEVIATAE RYLNE
//