ID L2GUQ6_VAVCU Unreviewed; 745 AA.
AC L2GUQ6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ATP-dependent DNA helicase CHL1 {ECO:0000256|ARBA:ARBA00017386};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=ATP-dependent DNA helicase chl1 {ECO:0000256|ARBA:ARBA00016387};
DE AltName: Full=Chromosome loss protein 1 {ECO:0000256|ARBA:ARBA00029709};
GN ORFNames=VCUG_01375 {ECO:0000313|EMBL:ELA47102.1};
OS Vavraia culicis (isolate floridensis) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Vavraia.
OX NCBI_TaxID=948595 {ECO:0000313|EMBL:ELA47102.1, ECO:0000313|Proteomes:UP000011081};
RN [1] {ECO:0000313|Proteomes:UP000011081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=floridensis {ECO:0000313|Proteomes:UP000011081};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Becnel J., Sanscrainte N., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The genome sequence of Vavraia culicis strain floridensis.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR EMBL; GL877424; ELA47102.1; -; Genomic_DNA.
DR RefSeq; XP_008074395.1; XM_008076204.1.
DR AlphaFoldDB; L2GUQ6; -.
DR STRING; 948595.L2GUQ6; -.
DR GeneID; 19879253; -.
DR VEuPathDB; MicrosporidiaDB:VCUG_01375; -.
DR HOGENOM; CLU_006515_2_1_1; -.
DR InParanoid; L2GUQ6; -.
DR OMA; HAINQSI; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000011081; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 2.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011081}.
FT DOMAIN 1..366
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 745 AA; 84695 MW; 236E6E13C8203113 CRC64;
MHSLNVTLYD SQKDFIEKAQ RTIENNQVAI FSSPTGTGKT LSLLLSIVPY IEKHVISDFS
GVSSANRALI NELNFNDTPI YYCSRTHSQL NQAINELKKL KIACNAVVLG SRMLYCKHTS
VNSLDNLEMM NERCKELREK DKCEYFLNLN GDLDTIRSEL DGYILSNGAT QTTSNKESYL
KTGTLSKAML KLENKAGFSS KKLGNEINAS GLFSKQTVPV NGLGSETNGR YSAFTNNNKD
STSMYKAATH SGAISFVNEG IYDIEDLKSS SCNFCPYYKS KELSKSASIK FLPYQMLFSK
DARDSFKLQI KDSIIIIDEA HNIYESVIQM NSVSVSYHLI KKYIKAFSKY RARFSQKCDA
TQVPSLDNCR ANGFTQGKVI ADAFLDILGH LDNFCECNKN QALTEEKCLR VNDFLVKSHL
QNYNMFRLKE YMRSTSLTQK LEGYEKDLHF GLYTIVNFLV LLTNSDSNGL ILYDMSKIRF
TPLDPKLYFE DVLECKSLIL AGGTMEPLNN LLCILKNASV FSYGSICKNF AAYLLADGPS
GKKLRLTYEH RENSQTLNEL FNTINNLINN ARSALQKRST YGGIICFLPS KNFLKIVRER
FDSKCNSDVS YVFEDLKQFT KECSTKTTVL FAVMGGRLSE GINFSDHFCR LLIIVGIPFP
SMNVEIKERI KFHGRDYTTI IALKTVNQAL GRALRHKHDH SGIVLIDERY DKLQYLLSPW
IREKIRKVKF GELFKELHFF LRTCQ
//
