ID L2GWU6_VAVCU Unreviewed; 228 AA.
AC L2GWU6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=(d)CMP kinase {ECO:0000256|ARBA:ARBA00012906};
DE EC=2.7.4.25 {ECO:0000256|ARBA:ARBA00012906};
GN ORFNames=VCUG_00888 {ECO:0000313|EMBL:ELA47565.1};
OS Vavraia culicis (isolate floridensis) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Pleistophoridae;
OC Vavraia.
OX NCBI_TaxID=948595 {ECO:0000313|EMBL:ELA47565.1, ECO:0000313|Proteomes:UP000011081};
RN [1] {ECO:0000313|Proteomes:UP000011081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=floridensis {ECO:0000313|Proteomes:UP000011081};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Becnel J., Sanscrainte N., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The genome sequence of Vavraia culicis strain floridensis.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CMP = ADP + CDP; Xref=Rhea:RHEA:11600,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58069, ChEBI:CHEBI:60377,
CC ChEBI:CHEBI:456216; EC=2.7.4.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001097};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dCMP = ADP + dCDP; Xref=Rhea:RHEA:25094,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57566, ChEBI:CHEBI:58593,
CC ChEBI:CHEBI:456216; EC=2.7.4.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001115};
CC -!- SIMILARITY: Belongs to the cytidylate kinase family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009427}.
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DR EMBL; GL877415; ELA47565.1; -; Genomic_DNA.
DR RefSeq; XP_008073910.1; XM_008075719.1.
DR AlphaFoldDB; L2GWU6; -.
DR STRING; 948595.L2GWU6; -.
DR GeneID; 19878771; -.
DR VEuPathDB; MicrosporidiaDB:VCUG_00888; -.
DR HOGENOM; CLU_079959_0_2_1; -.
DR InParanoid; L2GWU6; -.
DR OMA; RAITWWM; -.
DR OrthoDB; 2785826at2759; -.
DR Proteomes; UP000011081; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004127; F:cytidylate kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02020; CMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00238; Cytidyl_kinase_type1; 1.
DR InterPro; IPR003136; Cytidylate_kin.
DR InterPro; IPR011994; Cytidylate_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00017; cmk; 1.
DR PANTHER; PTHR21299:SF2; CYTIDYLATE KINASE; 1.
DR PANTHER; PTHR21299; CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE; 1.
DR Pfam; PF02224; Cytidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:ELA47565.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011081};
KW Transferase {ECO:0000313|EMBL:ELA47565.1}.
FT DOMAIN 7..216
FT /note="Cytidylate kinase"
FT /evidence="ECO:0000259|Pfam:PF02224"
SQ SEQUENCE 228 AA; 26208 MW; 5FA403FA1C9A00E2 CRC64;
MAKVFEIAID GHAGVGKSTT AKRVADFFGY THINSGDIYR AITYVFLKEY GSTKEDFRKG
LNRDQLGFLR TVKIENNRNA FLYKGKPCEL RTDDVNAFVP YIAQIKEVRD HVHKIQNRLI
RHETKGIVMD GRDIGSNIMP NAELKVYLTA SAEVRAMRRF KESDGDYDDI LAQIKNRDFM
DTNRKHAPLV KTSDAFEINN DCLTFDEQVK IIIDKVMEIK KKECDGYL
//
