ID L5JMJ7_PTEAL Unreviewed; 757 AA.
AC L5JMJ7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 {ECO:0000313|EMBL:ELK00157.1};
GN ORFNames=PAL_GLEAN10025258 {ECO:0000313|EMBL:ELK00157.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00157.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB031158; ELK00157.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JMJ7; -.
DR STRING; 9402.L5JMJ7; -.
DR eggNOG; KOG1419; Eukaryota.
DR InParanoid; L5JMJ7; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..190
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 272..459
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 250..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83720 MW; F7EB3B581EB289F5 CRC64;
MIVVFGLEFI IRIWSAGCCC RYRGWQGRLR FARKPFCVID TIVLIASIAV VSAKTQGNIF
ATSALRSLRF LQILRMVRMD RRGGTWKLLG SVVYAHSKEL ITAWYIGFLV LIFSSFLVYL
VEKDANKEFS TYADALWWGT ITLTTIGYGD KTPLTWLGRL LSAGFALLGI SFFALPAGIL
GSGFALKVQE QHRQKHFEKR RNPAANLIQC VWRSYAADEK SVSIATWKPH LKALHTCSPT
NQKLSFKERV RMASPRGQSI KSRQASVGDR RSPSTDITAE GSPTKVQKSW SFNDRTRFRP
SLRLKSSQPK PVIDADTALG TDDVYDEKGC QCDVSVEDLT PPLKTVIRAI RIMKFHVAKR
KFKETLRPYD VKDVIEQYSA GHLDMLCRIK SLQTRVDQIL GKGQITSDKK SREKITAEHE
TTDDLSMLGR VVKVEKQVQS IESKLDCLLD IYQQVLRKGS ASALTLASFQ IPPFECEQTS
DYQSPVDSKD LSSSAQNSGC LTRSASANIS RGLQFILTPN EFSAQTFYAL SPTMHSQTTQ
VPMSQSDGSA VAATNNIANQ INAAPKPAAP TTLQIPPPLP AIKLLPRPDT LHPTPPGLQE
SISDVTTCLV ASKENVQVAQ SNLTKDRSLR KSFDMGGETL LSVHPVGPKD LGKSLSVQNL
IRSTEELNIQ LSGSESSGSR GSQDFYPKWR ESKLFITDEE VGPEETETDA FDAMPQPARE
SALASDSLRT GRSRSSQSIC KAGESTDALS LPHVKLK
//
