ID L5JMT8_PTEAL Unreviewed; 345 AA.
AC L5JMT8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN ORFNames=PAL_GLEAN10018627 {ECO:0000313|EMBL:ELK00660.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00660.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; KB031156; ELK00660.1; -; Genomic_DNA.
DR RefSeq; XP_006926158.1; XM_006926096.1.
DR AlphaFoldDB; L5JMT8; -.
DR STRING; 9402.L5JMT8; -.
DR GeneID; 102879059; -.
DR KEGG; pale:102879059; -.
DR CTD; 222537; -.
DR eggNOG; KOG3704; Eukaryota.
DR InParanoid; L5JMT8; -.
DR OrthoDB; 10019at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF46; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transferase {ECO:0000256|RuleBase:RU361155, ECO:0000313|EMBL:ELK00660.1}.
FT DOMAIN 90..334
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 99
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 99..103
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 182
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 190
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 292
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 308..312
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 293..303
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 345 AA; 40336 MW; 0B42FB668C73A858 CRC64;
MLFKQQAWLR QKILVLGSLA VGSLLYLVAR VGSLDRLQPI CPIEGRFGAH GQAEFPLRAL
QFKRGLLHEF RKGNASKEQV RLHDLVQQLP KAIIIGVRKG GTRALLEMLN LHPAVVKASQ
EIHFFDNDEN YAKGIEWYRK KMPFSYPQQI TIEKSPAYFI TEEVPERIYK MNSSIKLLII
VREPTTRAIS DYTQVLEGKE RKNKTYYKFE KLAIDPNTCE VNTKYKAVRT SIYTKHLERW
LKYFPIEQFH VVDGDRLITE PLPELQLVEK FLNLPPRISQ YNLYFNATRG FYCLRFNIIF
NKCLAGSKGR IHPEVDPSVI TKLRKFFHPF NQKFYQITGR TLNWP
//