ID   L5JMX8_PTEAL            Unreviewed;       862 AA.
AC   L5JMX8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Chordin {ECO:0000256|ARBA:ARBA00016968};
GN   ORFNames=PAL_GLEAN10018201 {ECO:0000313|EMBL:ELK00769.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00769.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the chordin family.
CC       {ECO:0000256|ARBA:ARBA00007156}.
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DR   EMBL; KB031155; ELK00769.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5JMX8; -.
DR   STRING; 9402.L5JMX8; -.
DR   eggNOG; ENOG502QR4J; Eukaryota.
DR   InParanoid; L5JMX8; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0007389; P:pattern specification process; IEA:UniProt.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   Gene3D; 6.20.200.20; -; 1.
DR   InterPro; IPR016353; Chordin.
DR   InterPro; IPR010895; CHRD.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR46526; CHORDIN; 1.
DR   PANTHER; PTHR46526:SF1; CHORDIN; 1.
DR   Pfam; PF07452; CHRD; 3.
DR   Pfam; PF00093; VWC; 2.
DR   PIRSF; PIRSF002496; Chordin; 1.
DR   SMART; SM00754; CHRD; 4.
DR   SMART; SM00214; VWC; 3.
DR   SUPFAM; SSF57603; FnI-like domain; 3.
DR   PROSITE; PS50933; CHRD; 4.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473, ECO:0000256|PROSITE-
KW   ProRule:PRU00230}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          108..217
FT                   /note="CHRD"
FT                   /evidence="ECO:0000259|PROSITE:PS50933"
FT   DOMAIN          219..342
FT                   /note="CHRD"
FT                   /evidence="ECO:0000259|PROSITE:PS50933"
FT   DOMAIN          343..464
FT                   /note="CHRD"
FT                   /evidence="ECO:0000259|PROSITE:PS50933"
FT   DOMAIN          470..590
FT                   /note="CHRD"
FT                   /evidence="ECO:0000259|PROSITE:PS50933"
FT   DOMAIN          646..706
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   REGION          83..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   862 AA;  92594 MW;  382E9FAD53612C47 CRC64;
     MRCVLCACET VSDLNPLWPR PSRQPQWGRR MRGPGRVSCK NIKPECPALS CGQPRQLPGH
     CCQTCPQERS GTERQPMGLA FEYPRDPEHR SYSDRGEPGA EDRARGDGHT DFVALLTGPR
     SQAVARARVS LLRSSLRFSI SYRQLDRPTR IRFSDSTGSV LFEHPAAPTQ DGLVCGVWRA
     VPRLSLRLLR AEQLHVALVT PTHPSGEVWG PLMRHRALAA ETFSAILTLE GPSHQGTGGI
     TLLTLSDTED SLHFLLLFRG LLESRSGELA QVPLRLQILH QGQLLRELQT NASAQDPGFA
     EVLPNLTAKE MDWLVLGELQ MALERAGGPG LRISGHIAAR QNCDVLQSVL CGADALIPVQ
     TGAAGSASLK LLGNGSLIYQ VQVVGTGSEV VAMTLETKPQ RRDQRTVLCH MAGLQPGGHM
     AVGVCPGLGA RGTHMLLQNE LFLNVATKDF PDGELRGHVA ALPFSGHSAR HDTLPVPLAG
     ALVLPPVQSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TITAHLFGPP GIPGPRRLLK
     GFYGPEAQGV VKDLEPELLQ HLAQGTASLL ITTKGSPQGE LRGQVHITNQ CEVGGLRLAE
     AGAEGTPKAG ASDVPEVAVP ALPAVLGPDT PASTKPGSPW RARDPNTCFF EGQQRSHGAR
     WAPNYDPLCS LCTCQRRTVI CDPVVCPLPS CLSPVQAPDQ CCPVCPGCYF DGDRSWRAAG
     TRWHPVVPPF GLIKCAVCTC KGDTGEVHCE KVQCPRLACA QPVRANPTDC CKQCPVGSGA
     QPQLGDPMQA DGPRGCRFAG QWFPESQSWH PSVPPFGEMS CITCRCGAGV PHCERDDCSL
     PLSCIPGKEN RCCSHCTLQR RK
//