ID L5JPC8_PTEAL Unreviewed; 515 AA.
AC L5JPC8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=ETS translocation variant 5 {ECO:0000313|EMBL:ELK00782.1};
GN ORFNames=PAL_GLEAN10018216 {ECO:0000313|EMBL:ELK00782.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00782.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; KB031155; ELK00782.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JPC8; -.
DR STRING; 9402.L5JPC8; -.
DR eggNOG; KOG3806; Eukaryota.
DR InParanoid; L5JPC8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR006715; ETS_PEA3_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF160; ETS TRANSLOCATION VARIANT 5; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF04621; ETS_PEA3_N; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 373..453
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 136..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 58479 MW; DADF77F9E9864FDE CRC64;
MDGFYDQQVP FMVPGKSRTE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE
GKFLGSQVPD DEQFVPDFQS DNLVLHAPPP TKIKRELHSP SSELSSCSHE QALGANYGEK
CLYNYCAYDR KPPSGFKPLT PPTTPLSPTH QNSLFPPPQT TLPTSAHPAA AGPVQGVGPA
PTPHSLPDPG PQQQTFAVPR PPHQPLQMPK MMPENQYPTE QRFQRQLSEP CHPFPPQSGV
PGDNRPSYHR QMSEPIVPAA PPPPQGFKQE YHDPLYEHGV PGMPGPPAHG FQSPMGIKQE
PRDYCVDSEV PNCQSSYMRG GYFSSSHEGF SYEKDPRLYF DDTCVVPERL EGKVKQEPTM
YREGPPYQRR GSLQLWQFLV TLLDDPANAH FIAWTGRGME FKLIEPEEVA RRWGIQKNRP
AMNYDKLSRS LRYYYEKGIM QKVAGERYVY KFVCDPDALF SMAFPDNQRP FLKAESECHL
NEEDTLPLTH FEDNPAYLLD MDRCSSLPYA EGFAY
//
