ID   L5JPN6_PTEAL            Unreviewed;       498 AA.
AC   L5JPN6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Transmembrane protein 200A {ECO:0000313|EMBL:ELK00726.1};
GN   ORFNames=PAL_GLEAN10018705 {ECO:0000313|EMBL:ELK00726.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00726.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMEM200 family.
CC       {ECO:0000256|ARBA:ARBA00005308}.
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DR   EMBL; KB031156; ELK00726.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5JPN6; -.
DR   STRING; 9402.L5JPN6; -.
DR   eggNOG; KOG4823; Eukaryota.
DR   InParanoid; L5JPN6; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018787; DUF2371_TMEM200.
DR   PANTHER; PTHR31815; AGAP005329-PA; 1.
DR   PANTHER; PTHR31815:SF0; TRANSMEMBRANE PROTEIN 200A; 1.
DR   Pfam; PF10177; DUF2371; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        69..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          28..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..441
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  55042 MW;  2B3E40DB932D9F0D CRC64;
     MLVKEQAMIA TGGVITGLAA LKRQDSARSQ HHVNLSPSPA AQEKKPVRRR PRADVVVVRG
     KIRLYSPSGF FLILGVLISI VGIAMAVLGY WPQKEHFIDA ETTLSTNETQ VIRNQGGVVV
     SFFEQHLHSD KMKMLGPFTM GIGIFIFICA NAILHENRDK ETKIIHMRDI YSTVIDIHTL
     RIKEQKHING IYTGLMGETE VKQNGSSCAS RLAANTIASF SGFRSSFRMD SSVEEDELVL
     NESKSFGHLM PPLLSNSSVS VFGLYPPSSQ TTDDKTNGPK KCETKSIVSS SISAFTLPVI
     KLNNCVIDEP SIDNITEDAE NLKSRSRNLS MDSLVVPLPK TSESFQPVGM ALPRNNSIGE
     SLSSQYKSSV ALGPTAGQLL SPGAARRQFG SNTSLNLLSS HSKSLDLDRG PSTLTVQAEQ
     RKHPSWPRLD RSNSKGYMKL ENKEDPMERL LVPQAVIKKD FTNKEKLLMI SRSHNNLSFE
     HDEFLSNNLK RGTSETRF
//