ID L5JPP3_PTEAL Unreviewed; 209 AA.
AC L5JPP3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Syntaxin-7 {ECO:0000256|ARBA:ARBA00040006};
GN ORFNames=PAL_GLEAN10018717 {ECO:0000313|EMBL:ELK00736.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00736.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: May be involved in protein trafficking from the plasma
CC membrane to the early endosome (EE) as well as in homotypic fusion of
CC endocytic organelles. Mediates the endocytic trafficking from early
CC endosomes to late endosomes and lysosomes.
CC {ECO:0000256|ARBA:ARBA00037599}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00037832}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037832}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00037867}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037867}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR EMBL; KB031156; ELK00736.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JPP3; -.
DR STRING; 9402.L5JPP3; -.
DR eggNOG; KOG0811; Eukaryota.
DR InParanoid; L5JPP3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF90; SYNTAXIN-7; 1.
DR Pfam; PF14523; Syntaxin_2; 1.
DR SMART; SM00503; SynN; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 165..209
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
SQ SEQUENCE 209 AA; 24030 MW; 30C1F6AE0BEFE83A CRC64;
MSYTPGIVGD PTQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSLELRQ QLQQKQQYTN
QLAKETDKYI KDFGSLPTTP SEQRQRKIQK DRLVAEFTAS LTNFQKVQRQ AAEKEKEFVA
RVRAGSRLSS AFPEETAKER NLVSWESQTQ PQVQVQDDEI TEDDLHLIHE RESSIRQLEA
DIMDINEIFK NLGMMIHEQG DVIGKPKPY
//
