ID L5JRH1_PTEAL Unreviewed; 664 AA.
AC L5JRH1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Rho GTPase-activating protein 18 {ECO:0000313|EMBL:ELK00723.1};
GN ORFNames=PAL_GLEAN10018702 {ECO:0000313|EMBL:ELK00723.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00723.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031156; ELK00723.1; -; Genomic_DNA.
DR RefSeq; XP_006926221.1; XM_006926159.2.
DR AlphaFoldDB; L5JRH1; -.
DR STRING; 9402.L5JRH1; -.
DR GeneID; 102895128; -.
DR KEGG; pale:102895128; -.
DR CTD; 93663; -.
DR eggNOG; KOG2200; Eukaryota.
DR InParanoid; L5JRH1; -.
DR OrthoDB; 11483at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 325..524
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 15..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 75081 MW; FE141C9A52027108 CRC64;
MSWLSSSQGV VLTAYHHSGK DQAVGESHGK GGEEATSSRR YGQYALNQEI TKVKEKPPFD
RSSSQDSVDE LSMEDYWAEL ENIKKSSENR QEDQEVVVVK EPDEGELEEE WLKEAGLSNL
FGESAEDPQE SMVFLSTLTR TQAAAVQKRV ETVSQTLRKK NKQYQIPDVR DIFAQQRESK
EKAPDGTESQ SVRTNENKYQ GKDDQASNLD VGEKEQILPV PEETPASETD INLEVSFAEQ
AVNQKESSKD GTQKSQGNNT LLPNFRLPID KTGTTRIGDL APQDMKKVCY LALIELTALY
DVLGIELKQQ KAVKIKTKDS GLFCVPLTVL LEQDQKKVPG TKIPLIFQKL ISRIEEGGLE
TEGLLRIPGA AIRIKNLCQE LEAKFYEGTF NWDSVKQHDA ASLLKLFVRE LPQPLLSVEY
LKAFQAVQNL PTKKQQLQAL NLLVILLPDA NRDTLKALLE FLQRVIDNKE KNKMTVMNVA
MVMAPNLFMC HALDLKSSEQ REFVMAAGTA NIMNLLIKYQ KLLWTIPKFL VNQVRKQNTE
NLKKDKKMMK KLLKKMAYDR EKYEKQDKSA NDADVPQGVI RVQAPHLSKV SMAIQLTEEL
KASDVLARFL SQESGIAQTL KKEELFLYEI GGNIGERCLD DETYMKDLYQ LNPNAEWVIK
SKPS
//
