ID L5JRZ1_PTEAL Unreviewed; 630 AA.
AC L5JRZ1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Tripartite motif-containing protein 25 {ECO:0000313|EMBL:ELK01697.1};
GN ORFNames=PAL_GLEAN10019761 {ECO:0000313|EMBL:ELK01697.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK01697.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031150; ELK01697.1; -; Genomic_DNA.
DR RefSeq; XP_015454759.1; XM_015599273.1.
DR AlphaFoldDB; L5JRZ1; -.
DR STRING; 9402.L5JRZ1; -.
DR GeneID; 102879209; -.
DR KEGG; pale:102879209; -.
DR CTD; 7706; -.
DR eggNOG; KOG2177; Eukaryota.
DR InParanoid; L5JRZ1; -.
DR OrthoDB; 5359093at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19842; Bbox1_TRIM25-like_C-IV; 1.
DR CDD; cd19776; Bbox2_TRIM25_C-IV; 1.
DR CDD; cd16597; RING-HC_TRIM25_C-IV; 1.
DR CDD; cd13736; SPRY_PRY_TRIM25; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR042753; TRIM25_SPRY_PRY.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF40; E3 UBIQUITIN_ISG15 LIGASE TRIM25; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 12..53
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 438..630
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 351..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 223..257
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 380..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 70890 MW; B9FF5D0F8E5FDB6D CRC64;
MAELSLADEL MCSICLEPFK VPVTTPCGHN FCASCLDETW AVQGAPYLCP QCRAEYQTRP
QLHKNTVLCA VVEQFLQAEL ARVAVPDDWT PPVRAAAPSP TSQVACDHCL KAAAIKTCLV
CMASFCQEHL RPHLDSPAFR DHPLQPPVPD LLHRKCPQHN RLRDLFCPEH SECICHICLV
EHKTCSPVSL SQASADMEAK LKHKLTIMYS QINGASRALE DVRARQQDVR DAAQRKMEQL
RQEYLEMKAL IDASEASSTR KVKEEEKRVS SKFDNIYQIL LKKKSEIQAV KEDIELALTK
GDEFEFLEKA AKLQGISTKP VYVPKVELNH ELIRGICQNT TDLKNELKRY IRQPQKPEEP
TVSGDPTEHG AAPTHKPSRP VKKIVKEEKK AKKLPSTIMS PSKTLTFGAP EQLVDLKQVS
LESKAATLQP NSESLKAKVL ETFLAKSRPE LLEYAVKVIL DYNTANNKVA LSENYTVASV
ADTQQNYRPH PQRFTYCSQV LGLHCYKKGI HYWEVELQKN NFCGMGICYG SMERNGPESR
LGRNSASWCV EWFNTKISAW HNNVEKTLPS TKATRVGVLL NCDHGFVIFF AVTTDKVHLM
YKFKENFTEA LYPAFWVFSA GATLSIGSAK
//
