ID L5JT56_PTEAL Unreviewed; 776 AA.
AC L5JT56;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Elongin-A {ECO:0000256|ARBA:ARBA00021346};
GN ORFNames=PAL_GLEAN10015160 {ECO:0000313|EMBL:ELK02147.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK02147.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
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DR EMBL; KB031148; ELK02147.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JT56; -.
DR STRING; 9402.L5JT56; -.
DR eggNOG; KOG2821; Eukaryota.
DR InParanoid; L5JT56; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141:SF75; ELONGIN-A; 1.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:ELK02147.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Protein biosynthesis {ECO:0000313|EMBL:ELK02147.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 1..80
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT DOMAIN 567..611
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 80..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87877 MW; EAABC98F0EB41C22 CRC64;
MESKPGFEMN TPSVTSGPIL NVGFVELLKY LKKLSTLPIT VDILAETGVG KTVNSLRKHE
HVGNFARDLV AQWKKLVPVE RNTEPDEHDF EKNSSRKRPR DALQKEEEIE GDYHENWKAS
SSRPYSPDHR QKKHRKLSEL ERPHKASHGQ ERRDERKRGH RVSPIYSSDH ESSDYGHVQS
PPSSTSPHQM SVDHYRSLEE DHEPFASQQK PGKGHSNAFQ DRLGVSQERH LGEPQGKGVV
SQNKEHKYSH KEKRPVESRG DEKSSLSREK PHKAISKEEN RRPLSGDGTK EKLPSSGVKK
EKEREGSTKK FLSTLEIASD NHLKKQKHKN SEKTKSDKNK QSLDSLDIGK GAGDLLPKTK
EKVSNNLKTR EGKGKTPHSD RKSVGSLPKV EETDMDDEFE QPTMSFESYL SYDQPRKKKK
KIVKTATTVG EKGLKKNDSK STSKNLDSVQ KLPKVNENKS EKLQLTGADS AKPRKVPADA
LPVLPDIPLP MIQANYRPLP SLELISSFQP KRKAHSSPQE EEEAGFTGRR MNSKMQVYSG
SKCAYLPKMM TLHQQCIRVL KNNIDSIFEV GGVPYSVLEP VLERCTPEQL YRIEEYNHVL
IEETDQLWKV HCHRDFKEER PEEYESWREM YLRLQDAREQ RLRVLTKNIR SAHANKPKGR
QAKMAFVNSV AKPPRDVRRR QEKFGTGGAA VSEKIKIKPA PYSTGSSHAP SSSGSSNSFN
ASPEELAYDG PSTSSAHLAP VVSSTVSYDP RKPTVKKIAP MMAKTIKAFK NRFSRR
//
