ID   L5JUK8_PTEAL            Unreviewed;      1089 AA.
AC   L5JUK8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Dyslexia-associated protein KIAA0319-like protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PAL_GLEAN10014966 {ECO:0000313|EMBL:ELK01978.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK01978.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB031148; ELK01978.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5JUK8; -.
DR   STRING; 9402.L5JUK8; -.
DR   eggNOG; ENOG502QR8M; Eukaryota.
DR   InParanoid; L5JUK8; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 4.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029865; KIAA0319-like.
DR   InterPro; IPR013980; MANSC_dom.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR46182:SF3; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46182; FI19480P1; 1.
DR   Pfam; PF18911; PKD_4; 1.
DR   SMART; SM00089; PKD; 5.
DR   SUPFAM; SSF49299; PKD domain; 4.
DR   PROSITE; PS50986; MANSC; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        970..995
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          49..127
FT                   /note="MANSC"
FT                   /evidence="ECO:0000259|PROSITE:PS50986"
FT   DOMAIN          524..593
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          163..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1061..1089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1089 AA;  120693 MW;  418D5AFC7B96AEDD CRC64;
     MEKRLGIKPS PASWILSGFC WLTSVKWLRS LYPFYTYFCF SALWLSTDAS ESRCQQVKTQ
     FGVGVRSGGG NHLWLLEGTP SLQSCWAACC QDSACHALWW LEGMCIQADC SRPQSCQPFR
     TDSSNSMLVF LKKSQTADDL GFPPEDGVPH ILGLDWSRAS WRRQSPPRAP LRPTVSSSDQ
     QNLLRKLRKR ESPSEEITPV VTQHSDVNDS KELGDQNING SEEVHKEVTI SNPLTTNLTE
     ETAVWSKNVS VQPEVSEDLG TTPSTQQVKN PGKIQVAAPL PVAPSNSYAT PTPQASFQST
     SAPFPVIKEL VVSAGESVQM TLPKNEVQLN AYVLQEPLEG ETYTYDWQLI THPKDYSGEM
     EGKHSRILKL SKLTPGLYEF KVIVGGQSSH GEGYVNVTVK PEPRKNRPPV AVVSPQFQEI
     SLPTTSTVID GSQSTDDDKI VQYHWEELKG PLREEKISED TAILKLSKLV PGNYTFSLTV
     VDSDGATNST TASLTVNKAV DYPPVANAGP NQVITLPQNS ITLFGNQSTD DHGISSYEWS
     LSPSSKGKVV EMQGVRTPTL QLSAMQEGDY TYQLTVTDTI GQQATAQVTV IVQPENNKPP
     QADAGPDKEL TLPVDSTTLD GSRSSDDQKI ISYLWEKTQG PDGVQLENAN SSVATVTGLQ
     VGTYVFTLTV KDERNLQSQS SVNVIVKEEI NKPPVAKITG NVVITLPTDT AELDGSKSSD
     DKGIVSYLWT RDEGSPAAGE VLNHSDHRPI LFLSNLVEGT YTFHLKVTDV KGESDTDQTT
     VEVKPDPRKN NLVEIILDVN VSQLTERLKG MFIRQIGVLL GVLDSDIIVQ KIQPYTEQST
     KMVFFVQDEP PHQIFKGHEM AVMLKSELRK QKADFLIFRA LEINTVNEPP HQIFKGHEMA
     VMLKSELRKQ KADFLIFRAL EINTVTCQLN CSDHGHCDSF TKRCICDPFW MENFIKVQLR
     DGDSNCEWSV LYVIIASFVI VVALGILFWT VVCCCKRQKG KPRRKSKYKI LDATDQESLE
     LKPTSRAGIK QKGPILSSSL MHSESELDSD DAIFTWPDRE KGKFLHGQNG SVPNGQTPLK
     ARSPREEIL
//