ID L5JUQ0_PTEAL Unreviewed; 2682 AA.
AC L5JUQ0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Ankyrin repeat and KH domain-containing protein 1 {ECO:0000313|EMBL:ELK03020.1};
GN ORFNames=PAL_GLEAN10016789 {ECO:0000313|EMBL:ELK03020.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK03020.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031114; ELK03020.1; -; Genomic_DNA.
DR STRING; 9402.L5JUQ0; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4369; Eukaryota.
DR InParanoid; L5JUQ0; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR CDD; cd22503; KH-I_ANKHD1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 7.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR008606; EIF4EBP.
DR InterPro; IPR047374; KH-I_ANKHD1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF5; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 9.
DR Pfam; PF05456; eIF_4EBP; 1.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 19.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 267..299
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 300..332
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 333..365
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 367..399
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 400..432
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 433..465
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 466..498
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 530..562
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 563..595
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 615..647
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 649..681
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1069..1101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1102..1134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1136..1168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1169..1201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1204..1236
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1238..1270
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1271..1303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1306..1338
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1339..1371
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1711..1781
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2004..2143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2275..2380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2662..2682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 794..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 747..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1517
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1650..1681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2297..2327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2682 AA; 285264 MW; 8D5FD1154B824CE8 CRC64;
MLTDGGGGGT SFEEDLDSVA PRSAPAGASE PPPPGGVGLG IRTVRLFGEA GPAPGVGGGG
SGAGGGDAAL DFKLAAAVLR TGGGGGASGS DEDEVSEVES FILDQEDLDN PVLKTTSEIF
LSSTTEGADL RTVDPETQAR LEALLEAAGI GKLSTADGKA FADPEVLRRL TSSVSCALDE
AAAALTRMKA ENGHNAGQID TRSLAEACSD GDVNAVRKLL DEGRSVNEHT GRRXXXXXXX
XXXXXYYELA QVLLAMHADV EDRGTKGDIT PLMAASSGGY LDIVKLLLLH DANVNSQSAT
GNTALTYACA GGFVDIVKVL LNEGANIEDH NENGHTPLME AASAGHVEVA RVLLDHGAGI
NTHSNEFKES ALTLACYKGH LDMVRFLLDA GADQEHKTDE MHTALMEACM DGHVEVARLL
LDSGAQVNMP ADSFESPLTL AACGGHVELA ALLIERGANL EEVNDEGYTP LMEAAREGHE
EMVALLLAQG ANINAQTEET QETALTLACC GGFSEVADFL IKAGADIELG CSTPLMEASQ
EGHLELVKYL LAAGANVHAT TATGDTALTY ACENGHTDVA DVLLQAGADL DKQEDMKTIL
EGIDPAKHQE HESEGGRTPL MKAARAGHLC TVQFLISKGA NVNRATANND HTVVSLACAG
GHLAVVELLL AHGADPTHRL KDGSTMLIEA AKGGHTNVVS YLLDYPNNVL SVPTTDVSQL
TPSSQDQSQV PRVPMHTLAM VVPPQEPDRT SQENSPALLG VQKGTSKQKS SSLQVADQDV
LPPFHPYQPL ECIVEETEGK LNELGQRISA IEKAQLKSLE LIQGEPLNKD KIEELKKNRE
EQVQKKKKIL KELQKVERQL QMKTQQQFTK EYLETKGQKD TVSLHQQCSH RGVFPEGEGD
GSLLEDHFSE FPQVDTILFK DNDVDDEQQS PPSAEQIDFV PVQPLSSPQC NFSSDLGSNG
TNALELQKVS GNHQIIGQPQ IAITGHDQGL LVQEPDGLMV ATPAQTLTDT LDDLIAAVSS
RVPTGSNSSS QTTECLTTEP CSQSPSNVAS QAMPPVYPSV DIDAHTESNH DTALTLACAG
GHEELVSVLI ARDAKIEHRD KKGFTPLILA ATAGHVGVVE ILLDKGGDIE AQSERTKDTP
LSLACSGGRQ EVVDLLLARG ANKEHRNVSD YTPLSLAASG GYVNIIKILL NAGAEINSRT
GSKLGISPLM LAAMNGHVPA VKLLLDMGSD INAQIETNRN TALTLACFQG RAEVVSLLLD
RKANVEHRAK TGLTPLMEAA SGGYAEVGRV LLDKGADVNA PPVPSSRDTA LTIAADKGHY
KFCELLISRG AHIDVHNKKG NTPLWLASNG GHFDVVQLLV QAGADVDAAD NRKITPLMSA
FRKGHVKVVQ YLVKEVNQFP SDIECMRYIA TITDKELLKK CHQCVETIVK AKDQQAAEAN
KNASILLKEL DLEKSREESR KQALAAKREK RKEKRKKKKE EQKRKQEEDE ENKPKENSEL
PEDEDEEEND EDVEQEVPIE PPSATTTTTI GISATSATFT NVFGKKRANV VTTPSTNRKN
KKNKTKETPP TAPLILPEQH ISLAQQKADK NKINGEPRGG GAGGNSDSDN LDSTDCNSES
SSGGKSQELN FAIDMNSSGD RRYPSLLLHS QDEKSATTSK PQTRLEGEVN PNSLSTSYKS
VSLPLNSPNI KLTLTSPKRG QKREEGWKEV VRRSKKLSVP ASVVSRIMGR GGCNITAIQD
VTGAHIDVDK QKDKNGERMI TIRGGTESTR YAVQLINALI QDPAKELEDL IPKNHIRTPA
STKSIHANFS SGVGTTATSS KNAFPLGAPP LVTSQATTLS TFQPTNKLNK NVPTNVRSSF
PVSLPLAYPH PHFALLAAQT MQQIRHPRLP MAQFGGTFSP SPNTWGPFPV RPVNPGNTNN
SPKHNNTGRL PNQNGTVLPS ESAGLATASC PITVSSVVAA SQQLCVTNTR TPSSVRKQLF
ACVPKTSPPA TVISSVTSTC SSLPSVSSAP ITSGQVPTTF LSSSTPQTQL SSQKMESFSA
MPPPKEKVST QDQPIANLCT PSSTANSCSS SASNTPGAPE THPSSSPTPP SNNTKEEAQP
SSVSDSSPMS MPFASNSEPA PLTLASPRLV AADNQDTNNL PQLAVPAPRV SHRMQPRGSF
YSVVPNATIH QDPQSIFVTN PVPLTPPQGP PATVQLSSAM NIMNGSQMHI NPANKSLPPT
FGPATLFNHF SSLFDSSQVP ANQGWGDGPL SSRVAADASF TVQSAFLGNS VLGHLENVHP
DNSKAPGFRP PAQRVSTSPV GLPSIDPSGS SPSSSSAPLT SFSGIPGTRV FLQGPAPVGT
PSFNRQHFSP HPWTSASNSC DSPIPSVSSG SSSPLSATXX XXXXXXXXXX XXXXXXXKIP
PPIGTERLAR IRQGGSVAQA PVGTSFVAPV GHSGIWSFGV NAMSESLSSW SQSVIGNHPM
HQQLSDPSTF SQHQPMERDD SGMVAPSNIF HQPMASSFVD FSKGLPISMY GGTIIPSHPQ
LADVPGGPLF NGLHNPDPAW NPMIKVIQNS TECTDAQQAS LLPSVPALKG EIPTPQLTRP
KKRVGQPMVA SPNQRDRLPD CYSTTPGGTL YATTPGGTRI IYDRKFLLEC KNSPIARTPP
CCLPQIPGVT TPTVLRSKLE ELKEQKETEE EIPDDAQFEM DI
//
