ID L5JXS2_PTEAL Unreviewed; 789 AA.
AC L5JXS2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Cadherin-22 {ECO:0000313|EMBL:ELK04259.1};
GN ORFNames=PAL_GLEAN10024421 {ECO:0000313|EMBL:ELK04259.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04259.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KB031072; ELK04259.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JXS2; -.
DR STRING; 9402.L5JXS2; -.
DR eggNOG; KOG3594; Eukaryota.
DR InParanoid; L5JXS2; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF311; CADHERIN-22; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..131
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 132..240
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 241..357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 358..462
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..579
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 661..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..702
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 85707 MW; D12396E216A7A469 CRC64;
MGRVKRGWVW NQFFVVEEYT GTEPLYVGKV KWGPAPAIPR PEPERHPLIH SDSDEGDGAI
KYTISGEGAG TIFLIDELTG DIHAMERLDR EQKTFYTLRA QARDRATNRL LEPESEFIIK
VQDINDSEPR FLHGPYIGSV AELSPTGTSV MQVMASDADD PTYGSSARLV YSLLDGEHHF
TVDPKTGVIR TAVPDLDRES QERYEVVIQA TDMAGQLGGL SGSTTVTIVV TDVNDNPPRF
PQKMYQFSIQ ESAPIGTAVG RVKAEDSDVG ENTDMTYHLK EESGSGGHVF KVTTDSDTQE
AIIVVQKRLD FESQPVHTVV LEALNKFVDP RFADLGTFRD QAIVRVAVTD VDEPPEFRPP
SGLLEVQEDA QVGSLVGVVT ARDPDAANRP VRYAIDHDSD LDQIFDIDAD TGAIVTGKGL
DRETAGWHNI TVLAMEADNH AQLSRASLRI RILDVNDNPP ELATPYEAAV CEDAKPGQLI
QTISVVDRDE PQGGHRFYFR LVPEAPSNPH FSLLDIQDNT AAVHTQHLGF NRQEQDVFFL
PILVVDSGPP TLSSTGTLTI RICGCDSSGT IQSCNTTAFV MAASLSPGAL IALLVCVLIL
VVLVLLILTL RRHHKSHLSS DEDEDMRDNV IKYNDEGGGE QDTEAYDMSA LRSLYDFGEL
KSGDGGGDGG PGGGPAGGPD SPPPSRLPSE RHSLPQGPPS PEPDFSVFRD FISRKVALAD
GDLTVPPYDA FQTYAFEGAD SPAASLSSLH SGSSGSEQDF AYLSSWGPRF RPLAALYAGH
RADDEAQAS
//
