ID L5JZJ0_PTEAL Unreviewed; 218 AA.
AC L5JZJ0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Synapse differentiation-inducing gene protein 1 {ECO:0000256|ARBA:ARBA00040240};
DE AltName: Full=Dispanin subfamily C member 2 {ECO:0000256|ARBA:ARBA00041354};
DE AltName: Full=Transmembrane protein 90B {ECO:0000256|ARBA:ARBA00042246};
GN ORFNames=PAL_GLEAN10002757 {ECO:0000313|EMBL:ELK04487.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04487.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: May regulate AMPA receptor content at nascent synapses, and
CC have a role in postsynaptic development and maturation.
CC {ECO:0000256|ARBA:ARBA00037790}.
CC -!- SUBUNIT: Homodimer. Interacts with GRIA1 and GRIA2.
CC {ECO:0000256|ARBA:ARBA00038680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell
CC projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR EMBL; KB031070; ELK04487.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JZJ0; -.
DR STRING; 9402.L5JZJ0; -.
DR eggNOG; ENOG502QQXK; Eukaryota.
DR InParanoid; L5JZJ0; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14768:SF3; SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1; 1.
DR PANTHER; PTHR14768; UPF0338 PROTEIN; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ELK04487.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 218 AA; 24470 MW; 6F761E8C8ECF086C CRC64;
MDGIIEQNSV LVHSKISDAG TRNGLINTRN FMAESRDGLV SVYPAPQYQS CRVVGSAASA
TLDSSRNETV QQLLDPNTLQ QSVESHYRPN IILYSEGMLH SLGDGVAADC CETTFIEDRS
PTKESLEYPD GKFIDLSAED IKIHTLSYDV EEEEEFQELE SNYSSDTESE DNFLMMPPRD
HLGLSVFSML CCFWPLGIIA FYLSHESTAA WFWVMLQT
//
