ID L5JZW9_PTEAL Unreviewed; 552 AA.
AC L5JZW9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein {ECO:0000256|ARBA:ARBA00019443};
GN ORFNames=PAL_GLEAN10014214 {ECO:0000313|EMBL:ELK04974.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04974.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC triphosphate receptor (ITPR) Ca(2+) release.
CC {ECO:0000256|ARBA:ARBA00003856}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004494}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004494}.
CC -!- SIMILARITY: Belongs to the ITPRIP family.
CC {ECO:0000256|ARBA:ARBA00005554}.
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DR EMBL; KB031059; ELK04974.1; -; Genomic_DNA.
DR RefSeq; XP_006920941.1; XM_006920879.2.
DR RefSeq; XP_015451876.1; XM_015596390.1.
DR RefSeq; XP_015451877.1; XM_015596391.1.
DR RefSeq; XP_015451878.1; XM_015596392.1.
DR AlphaFoldDB; L5JZW9; -.
DR STRING; 9402.L5JZW9; -.
DR GeneID; 102886445; -.
DR KEGG; pale:102886445; -.
DR CTD; 85450; -.
DR eggNOG; ENOG502QRDF; Eukaryota.
DR InParanoid; L5JZW9; -.
DR OrthoDB; 5299698at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.1410.40; -; 1.
DR InterPro; IPR026250; ITPRIP-like.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF8; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:ELK04974.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..552
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013084915"
FT DOMAIN 426..481
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT COILED 38..82
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 552 AA; 62923 MW; 8E0625B33F0261FF CRC64;
MALGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIILK MQAHHEKLQL EQLRLEEEVA
RLVAEKEALE RVEEEGQQQN ETRTAWDLWS TLCMILFLVI EVWRQDHQDG LSPECLGGDE
DELPGLEGAP LRGLTLPNKA TLDHFYEHCI RGATADAART REFVEGFVDD LLEALRSLCN
RDTDMEVEDF IGVDSMYENW QVDKPLLCHL FVPFIPPEPY HFHPELWCSS HSAPLDLQGY
GQIKVVRADE DTLGCICGKT KLGEDMLCLL HGKNNLVRPS SEVEDPLCAK GSPYLNTMQV
MKWFQTALTR AWHRIAHKYE FDLAFGQLDT PGSLKIRFRS GKFMPFNLIP VIQCDDSDLY
FVSHLPRELS GETPVSSTDW LLSFAVYERH FLRTTSKALP EGACHLSCLQ IASFLLSKQS
RLTGPSGLGN YHLKTALLHL LLSGRAADWK AGQLNARLHE LLRFLEKSLL EKKLHHFFIG
NRKLPDTMRL PEAVRRAEPL NLFRPFVLQR SLYRQTVDSF YELLKNAPTL ISEYSLHIPS
DHASLPQKAV IS
//