ID L5K009_PTEAL Unreviewed; 2155 AA.
AC L5K009;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Putative Polycomb group protein ASXL1 {ECO:0000313|EMBL:ELK04086.1};
GN ORFNames=PAL_GLEAN10024216 {ECO:0000313|EMBL:ELK04086.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04086.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Asx family. {ECO:0000256|ARBA:ARBA00006391}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KB031072; ELK04086.1; -; Genomic_DNA.
DR STRING; 9402.L5K009; -.
DR eggNOG; ENOG502QWT2; Eukaryota.
DR InParanoid; L5K009; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR InterPro; IPR026905; ASX-like_PHD.
DR InterPro; IPR024811; ASX/ASX-like.
DR InterPro; IPR028020; ASX_DEUBAD_dom.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13578; ADDITIONAL SEX COMBS LIKE PROTEIN ASXL; 1.
DR PANTHER; PTHR13578:SF19; POLYCOMB GROUP PROTEIN ASXL1; 1.
DR Pfam; PF13919; ASXH; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF13922; PHD_3; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 9..290
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 873..982
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 324..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1856..1916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 386..529
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 342..362
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 2155 AA; 236766 MW; 73128F74626F5CDE CRC64;
MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPRGVA HEMPKTFTFD
AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGVR GDPEKRGVIP
NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS
SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSNVIS ALVDGKSTHI
PYRDSKLTRL LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP
KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEEGDDK
DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAT EMLGAKIKAM
ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYSSL
QQEVDIKTKK LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF
IPLEEKSKIM NRSFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR
PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV DASSFESTAN
KKSKASGTSP LACLNAMLHS NSRGGEGLFY KLPGRISLFT LKKDALQWSR NPAAVEGEEP
EDTADVESCG SNETSTVSGE NDVSLDETSS NASCSTESQS RPLSSPRDSC RASSQANKQK
KKTGVMLPRV VLTPLKVNGA HVESASGFSG RHADGESGSP SSSSSGSLAL GSAAIRGQAE
VARDPAPLLR GFRKPATGQM KRNRGEEIDF ETPGSILVNT NLRALINSRT FHALPSHFQQ
QLLFLLPEVD RQVGTDGLLR LSSSALNNEF FTHAAQSWRE RLADGEFTHE MQVRIRQEME
KEKKVEQWKE KFFEDYYGQK LGLTREELLQ QNVVKEEAEI KSDLRVPGES ARPQRGPATR
QRDGHFKKRS RPDLRTRARR NLYKKQEPEQ GGNAKDTQSA TPDTPHYQHR EAKSDSAEAG
SPHLSDTSSA APDPKGPDFS AETGASRIQT NPDDLARACE SPDRIPTLPQ ETVDQEPKDQ
KRKSFEQAAS ASFPEKKPRL EDRQSFRNTI ESVHTEKPQP TKEEPKVPPI RIQLSRIKPP
WVVKGQPTYQ ICPRIVPITE PSCRAWTSAR TLADIKARAL QVRGARGHHC HREAATTAIG
GGGGPGGGDG RATDEGGGRG GSIGDGGETC GHPEPRGAPS TLGECASDLQ RTQLLPPHPL
NGEHTQAGTA TPRARREDLA SLREEDRCPL QRVPDILTSG LEDASQLPVV PTGDQPCQAL
PPVSSKTPAP ESVVEQPTSH PSVRTEYESS PTSWEKDNEE QEPTLPPENG LIQSLVGNVV
LEEETGQALD SDSNLTMKDP VNVTPSSTPE SSLVSCLQDR QFDDELGLGD SCPPTRESAT
RQEDLKAEAL ISSGAVPWMP GLSNDTVGQP ESDSRENVPS REPKVGEEWE EAAPLIPTLP
EGLTAEEGLH FPDNCPSLWT VPSQECVDSG GGDYKQVEVE KLKISGDSKA PSPHSESTDT
ASDFEGHLSE DSSEAAPSEA TVMKRSSVDK EEKHNRSGSA SLCKVNGDPS PVTRTDRMVA
SQSWVSRVCA IPPKIPDSLL LASTEYQPRP MPLGRPGSSV EATNPLVMQL LQGNLPLEKV
LPPALSDSKP KSPRLPLVKE QGMGSLHDPR ESSCAVDRNS PGSLRASKEP LLHDSREASS
GLARLEVIQA PGTPQKISKT VPSLDSLYPV TNSTTVSRKA EVDSKEQFSP FNFEEQKEAG
NLSQGSNSNA APDKSPGNHT TSRAPCFLSP NVVSLGPSQT GRPLGGQDSA GGQGKKLFGS
INEAAALPCP RPVEPMPLPA DAPPGFPSRK LGATKNSVSG GVQTAREDWA PKPPPASVGS
IKSEKSFVGV PLKMNAENRN AAGLGPRELV DHLQAMPFVL DLPFWKLPRE PGKGLSQPLE
PSSISSQLNI KQAFYGKLSK LQLSSTSFNY SSSSPTFPKG LAGSVVQLSH KANFGASHSA
SLSLQMFTDS STVESISLQC ACSLKAMIMC QGCGAFCHDD CIGPSKLCVL CLVVR
//
