ID L5K0S8_PTEAL Unreviewed; 367 AA.
AC L5K0S8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Cullin N-terminal domain-containing protein {ECO:0000259|Pfam:PF00888};
GN ORFNames=PAL_GLEAN10014141 {ECO:0000313|EMBL:ELK04917.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04917.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019}.
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DR EMBL; KB031059; ELK04917.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K0S8; -.
DR STRING; 9402.L5K0S8; -.
DR eggNOG; KOG2166; Eukaryota.
DR InParanoid; L5K0S8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR InterPro; IPR042652; CACUL1.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR46636; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46636:SF1; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00888; Cullin; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..291
FT /note="Cullin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00888"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 41250 MW; 044152C2205EDD3E CRC64;
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPPPPPP PRSSIPAPAR EPPGGQLLAV
PAISVDRKGP KEGLPMGPPP PPEANGVIMM LKSCDAAVAK AVPAPTPSST ININTSTSKF
LMNVITIEDY KSTYWPKLDG AIDQLLTQSP GDYIPISYEQ IYSCVYKCVC QQHSEQMYSD
LIKKITNHLE RVSKELQASP PDLYIERFNI ALGQYMGALQ SIVPLFIYMN KFYIETKLNR
DLKDDLIKLF TEHVAEKHIY SLMPLLLEAQ STPFQVTPST MANIVKGLYT LRPEWVQMAP
TLFSKFIPNI LPPALESELP EYAAQDQKLQ RELIQNGFMR QVFFFFFFLL QNISTFLGQF
VLAGEGC
//