ID L5K135_PTEAL Unreviewed; 1032 AA.
AC L5K135;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Myelin transcription factor 1 {ECO:0000313|EMBL:ELK04451.1};
GN ORFNames=PAL_GLEAN10024813 {ECO:0000313|EMBL:ELK04451.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04451.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR EMBL; KB031072; ELK04451.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K135; -.
DR STRING; 9402.L5K135; -.
DR eggNOG; KOG3803; Eukaryota.
DR InParanoid; L5K135; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 6.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF10; MYELIN TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 2.
DR Pfam; PF01530; zf-C2HC; 6.
DR SUPFAM; SSF103637; CCHHC domain; 6.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 470..525
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT DOMAIN 527..697
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 25..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 904..966
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 150..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 111129 MW; 676388DF8A7D147B CRC64;
MLCPVQLGAS LQSCPLAKKR KLDSTEAQHL ASKRKSQPLK LALDEGYSVD SDGSEDAAVK
DASVSGESEA TLEEDDAEMS GQDEIHRAEP AEGRSPITSR AASGPISSPA GPSRGYQELI
ATSLLNLGQV AEEALVREDS GQGARRGPGV VHLLRDEPEE GATSDEGDKD IFIQPEEAEE
VIEVTSERSL EGMSSEESSK PRVTLGDADG AEDEDEDEDE DEDGDADEDE DEDEDAAPGC
ICEDAAPCAP TPRAPEPASP EPAYSVLVEV RSDDGQDEDS RSQKSAVTDA SEMYDVMTRG
NLGLLEQAIA LKAEQGQPSP GEPAKGARPL DAPPRTCCGK DSSRAEKREI KCPTPGCDGT
GHVTGLYPHH RSLSGCPHKD RIPPEILAMH ENVLRCPTPG CTGQGHVNSN RNTHRSLSGC
PIAAAEKLAK SHEKQQPPTG DPAKSGSSSD RTLRPMCFVK QLEVPPYGSY RPSVAPATPR
ANLAKELEKF SKVTFDYASF DAQVFGKRML APKMPTSETS PKAFKCFDYT HDAEAAHMAA
TAILNLSTRC WEMPENLSTK PQEAPRKVVD IEVDENGTLD LSMHKHRRRE GALPGGSSSP
GVRPPDAPQR RDSGSAPSGS VTSPQPSQAS RQDEWDRPLD YTKPSRQREG EPEESEPAAH
SFASSEADDQ EALEESFEER RYPGDVTLTS FKLKFLSKDM KKELLTCPTP GCDGSGHITG
NYASHRSLSG CPLADKSLRN LMAAHSADLK CPTPGCDGSG HITGNYASHR SLSGCPRAKK
TGAKVTPAKD DKEDPELMKC PVPGCVGLGH ISGKYASHRS ASGCPLAARR QKEGSVNGPS
FSWKSLKNEG PTCPTPGCDG SGHANGSFLT HRSLSGCPRA TFAGKKGKLS GDEVLSTKFK
TSDVLDNDEE IKQLNQEIRD LSESNSEMEA AMAQLQSQVS SMERSLRSIE DENRLIEEQN
EALFLELSGL SQALIRSLAN IRLPHMEPIC EQNFDAYVST LTDMYSNQEC YQDPENKDLL
ESIKQAVRGI QV
//
