ID L5K194_PTEAL Unreviewed; 4850 AA.
AC L5K194;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative E3 ubiquitin-protein ligase HERC1 {ECO:0000313|EMBL:ELK05350.1};
GN ORFNames=PAL_GLEAN10023399 {ECO:0000313|EMBL:ELK05350.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK05350.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB031042; ELK05350.1; -; Genomic_DNA.
DR STRING; 9402.L5K194; -.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; L5K194; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 14.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 372..421
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 422..476
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 477..529
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 530..579
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 581..632
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 633..683
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 684..736
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2006..2197
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 3413..3454
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3611..3642
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3732..3773
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3986..4034
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4035..4089
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4090..4141
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4142..4193
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4195..4246
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4247..4298
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4299..4350
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4490..4837
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 125..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1401..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2261..2292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2405..2490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2612..2671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2688..2748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2794..2872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2405..2432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2433..2470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2476..2490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2618..2665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2688..2739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4800
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4850 AA; 530820 MW; D104DC490E9FD19E CRC64;
MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK
YHDKGKVKQQ QHSPESSSGS EDVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVNS MEKSKLLSSQ EGMISFDCFM
MILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE
ELAATRIVDI SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP
FPSSREHHNF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF
GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIINSL LLLPVSVARP
LLSYLLDLLP PLDCLNRLLP AAALLEDQEL QWPLHGGPEL IDPAGVPLPQ PAQSWVWLVD
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL
DTVSRFVLAA LLKHTNLLSQ ACGESRQYQP GKSLSEVYRC VYKVRSRLLA CKNLELIQTR
SSSRDRWVKL EIKNQDSADV DPQDHSFTRT IDEEAEMEEQ AERDREEGHP EPEDEEEERE
HEVMTAGKIF QCFLSAREVA RSRDRDRMNS GAGSGARADD PSPQSQQERR VSTDLPEGQD
VYTAACNSVI HRCALLILGV SPVIDELQKR REEGQLQQPS TSASEGGGLM TRSESLTAES
RLVHASPNYR LIKSRSESDL SQPESDEESY ALSGRRNVDL DLASSHRKRG PMHSQLESLS
DSWARLKYSR DWLCNSSYSF ESDFDLTKSL GVHTLIENVV SFVSGDVGNA PGFKEPEESM
STSPQASIIA MEQQQLRAEL RLEALHQILI LLSGMEEKGS ISLSGSRTSP GFQSSTLLTS
VRLQFLAGCF GLGTVGHAGA KGESGRLHHY QDGIRAAKRN IQIEIQVAVH KIYQQLSATL
ERALQANKHH IEAQQRLLLV TVFALSVHYQ PVDVSLAIST GLLNVLSQLC GTDTMLGQPL
QLLPKTGVSQ LSTALKVAST RLLQILAITT GTYADKLSPK VVQSLLDLLC SQLKNLLSQA
GVLLMASFGE GEGEEGEEEE KKVDSSGETE KRDFRAALRK QHAAELHLGD FLVFLRRVVS
SKAIQSKMAS PKWTEVLLNI ASQKCSSGIP LVGNLRTRLL ALHVLEAVLP ACESGVEDDQ
MAQVVERLFS LLSDCMWETP IAQAKHALQI KEKEQEIKLQ KQGELEEEDE NLPIQEVSFD
PEKAQCCLVE NGQILTHGSG GKGYGLASTG VTSGCYQWKF YIVKENRGNE GTCVGVSRWP
VHDFNHRTTS DMWLYRAYSG NLYHNGEQTL TLSSFTQGDF ITCVLDMEAR TISFGKNGEE
PKLAFEDVDA AELYPCVMFY SSNPGEKVKI CDMQMRGTPR DLLPGDPVCS PVAAVLAEAT
IQLIRILHRT DRWTYCINKK MMERLHKIKI CIKESGQKLK KSRSVQSREE NEMREEKESK
EEEKGKHSRH GLADLSEPQL RTLCIEVWPV LAVIGGVDAG LRVGGRCVHK QTGRHATLLG
VVKEGSTSAK VQWDEAEITI SDTPLYNLEP CEPLPFDVAR FRGLTASVLL DLTYLTGIHE
DISKQSIKRH EKKHRHESEE KGDVEQKTES ESALDMRTGL TSDDVKSQGT TSSKSENEIA
SFSLDPTLPG VESQHQIAEG KRKNHEHMSK NHDIAQSEIR AVQLSYLYLG AMKSLSALLG
CSKYAELLLI PKVLAENGHN SDCASSPVVH EDVEMRAALQ FLMRHMVKRA VMRSPIKRAL
GLADLERAQA MIYKLVVHGL LEDQFGGKMK QEIDQQAEES DQAQQAQTPV TTSPSASSTT
SFMSSSLEDT TTATTPVTDT ETVPASESPG VMPLSLLRQM FSSYPTTTVL PTRRAQTPPI
SSLPTSPSDE VGRRQSLTSP DSQSARPANR TALSDPSSRL STSPPPPAIA VPLLEMGFSL
RQIAKAMEAT GARGEADAQN ITVLAMWMIE HPGHEDEEEP QSGSTADSRH GAAVLGSGGK
SNDPCYLQSP GDIPSADAAE MEEGFSESPD NLDHTENAAS GSGPPARGRS AVTRRHKFDL
AARTLLARAA GLYRSVQAHR NQSRREGISL QQDPGALYDF NLDEELEIDL DDEAMEAMFG
QDLTSENDIL GMWIPEHVCE SEDREEVVVC ELCECSVVSF NQHMKRNHPG CGRSANRQGY
RSNGSYVDGW FGGECGSGNP YYLLCGSCRE KYLALKTKSK TTSSERYKGQ APDLIGKQDS
VYEEDWDMLD VDEDEKLTGE EEFELLAGPL GLNDRRIVPE PVQFPDSDPL GASVAMVTAT
NSMEETLMQI GCHGSVEKSS SGRITLGEQA AALANPHDRV VALRRVTAAA QVLLARTMVM
RALSLLSVSG SSCSLAAGLE SLGLTDIRTL VRLMCLAAAG RAGLSTSPSA MASTSERLRG
GHSKANKPIS CLAYLSTAVG CLASNTPSAA KLLVQLCTQN LISAATGVNL TTVDDPIQRK
FLPSFLRGIA EENKLVTSPN FVVTQALVAL LADKGAKLRP NYDKSEVEKK GPLELANALA
ACCLSSRLSS QHRQWAAQQL VRTLAAHDRD NQTTPQTLAD MGGDLRKCSF IKLEAHQNRV
MTCVWCNKKG LLATSGNDGT IRVWNVTKKQ YSLQQTCVFN RLEGDTEESL GSPSDPSFSP
VSWSISGKYL AGALEKMVNI WQVNGGKGLV DIQPHWVSSL AWPEEAPATA WSGESPELLL
VGRMDGSLGL IEVIDASTMY RRELEHCYRK DVSVTCIAWF SEDRPFAVGY FDGKLLLGTK
EPLEKGGIVL IDAHKDTLVS MKWDPTGHIL MTCAKEENVK LWGPISGCWR CLHSLCHPSI
VNGIAWCSLP GKGSKLHLLL ATGCQSGLVC VWRIPQDAVQ TSVASSEGWW DQESNCQDGY
RPPAGAKCVY QLRGHITPVR TVAFSSDGLA LVSGGLGGLM NIWSLRDGSV LQTVVIGSGA
IQTTVWIPDV GVAACSNRSK DVLVVNCTAE WTAANHVLAT CRTALKQQGI LGLNMAPCMR
AFLERLPMML QEQYAYEKPH VVCGDQLVHS PYMQCLASLA VGLHLDQLLC NPPVPPHHQN
CLPDPASWNP NEWAWLECFS TTIKAAEALT NGAQFPESFT VPDLEPVPED ELVFLMDNSK
WINGMDEQIM SWATSRPEDW HLGGKCDVYL WGAGRHGQLA EAGRNVMVPA AAPSFSQAQQ
VICGQNCTFV IQANGTVLAC GEGSYGRLGQ GNSDDLHVLT VISALQGFVV TQLVTSCGSD
GHSMALTESG EVFSWGDGDY GKLGHGNSDR QRRPRQIEAL QGEEVVQMSC GFKHSAVVTS
DGKLFTFGNG DYGRLGLGNT SNKKLPERVT ALEGYQIGQV ACGLNHTLAV SADGSMVWAF
GDGDYGKLGL GNSTAKSSPQ KVDVLCGIGI KKVACGTQFS VALTKDGHVY TFGQDRLIGL
PEGRARNHNR PQQIPVLAGV VIEDVAVGAE HTLALASTGD VYAWGSNSEG QLGLGHTNHV
REPTLVTVLQ GKNVRQISAG RCHSAAWTAP PVPPRAPGVS VPLQLGLPDA VPPQYGALRE
VSIHTARARL RLLYHFSDLM YSSWRLLNLS PNNQNSASHY NAGTWGIVQG QLRPLLAPRV
YTLPMVRSIG KTMVQGKNYG PQITVKRIST RGRKCKPIFV QIARQVVKLN ASDLRLPSRA
WKVKLVGEGA DDAGGVFDDT ITEMCQELET GIVDLLIPSP NATAEVGYNR DRFLFNPSAC
IDEHLMQFKF LGILMGVAIR TKKPLDLHLA PLVWKQLCCV PLTLEDLEEV DLLYVQTLNS
ILHIEDSGIT EESFHEMIPL DSFVGQSADG KMVPIIPGGN SIPLTFSNRK EYVERAIEYR
LHEMDRQVAA VREGMSWIIP VPLLSLLTAK QLEQMVCGMP EISVEVLKKV VRYREVDEQH
QLVQWFWHTL EEFSNEERVL FMRFVSGRSR LPANTADISQ RFQIMKVDRP YDSLPTSQTC
FFQLRLPPYS SQLVMAERLR YAINNCRSID MDNYMLSRNV DNAEGSDTDY
//
