ID L5K1F3_PTEAL Unreviewed; 840 AA.
AC L5K1F3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 {ECO:0000313|EMBL:ELK05172.1};
GN ORFNames=PAL_GLEAN10007544 {ECO:0000313|EMBL:ELK05172.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK05172.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR EMBL; KB031043; ELK05172.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K1F3; -.
DR STRING; 9402.L5K1F3; -.
DR eggNOG; KOG0705; Eukaryota.
DR InParanoid; L5K1F3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08855; ArfGap_AGAP3; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF2; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 356..570
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 591..711
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 750..782
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 416..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 91301 MW; 523BAB95DC239714 CRC64;
MQALQLAGGP PQQFALSNSA AIRAEIQRFE SVHPNIYAIY DLIERIEDLA LQNQIREHVI
SIEDSFVNSQ EWTLSRSVPE LKVGIVGNLS SGKSALVHRY LTGTYVQEES PEGGRFKKEI
VVDGQSYLLL IRDEGGPPEL QFAAWVDAVV FVFSLEDEIS FQTVYNYFLR LCSFRNASEV
PMVLVGTQDA ISAANPRVID DSRARKLSTD LKRCTYYETC ATYGLNVERV FQDVAQKVVA
LRKKQQLAIG PCKSLPNSPS HSAVSAASIP AVHINQATNG GSSAFSDYSS SVPSTPSISQ
RELRIETIAA SSTPTPIRKQ SKRRSNIFTS RKGADLDREK KAAECKVDSI GSGRAIPIKQ
GILLKRSGKS LNKEWKKKYV TLCDNGLLTY HPSLHDYMQN VHGKEIDLLR TTVKVPGKRL
PRATPTTAPG TSPRANGLAL ERSNTQLGGG TGAPHSASNP AWAGQRSCSV SSADQWSEAS
ALSPASGPAE VLSSSPKLEP PPSPHSNRKK HRRKKSTGTP RPDGPSSAAE EAEESFEFVV
VSLTGQTWHF EASTAEEREL WVQSVQAQIL ASLQGCRSAK DKTRLGNQNT ALAVQAVRTV
RGNSFCIDCD APNPDWASLN LGALMCIECS GTHRHLGAHL SRVRSLDLDD WPPELLAVMT
AMGNALANSV WEGALDGYAK PGPDACREEK ERWIRAKYEQ KLFLAPLPSS DVPLGQQLLR
AVVEDDLRLL VMLLAHGSKE EVNETYGDGD GRTALHLSSA MANVVFTQLL IWYGVDVRSR
DARGLTPLAY ARRAGSQECA DILIQHGCPG EGCGLAPTPS REPANGSTAS AELHRSPSLL
//
