ID L5K207_PTEAL Unreviewed; 3769 AA.
AC L5K207;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Vacuolar protein sorting-associated protein 13C {ECO:0000313|EMBL:ELK05362.1};
GN ORFNames=PAL_GLEAN10023412 {ECO:0000313|EMBL:ELK05362.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK05362.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB031042; ELK05362.1; -; Genomic_DNA.
DR STRING; 9402.L5K207; -.
DR eggNOG; KOG1809; Eukaryota.
DR InParanoid; L5K207; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF125; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 3.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 61..131
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 198..429
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 628..849
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1191..1288
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1705..1802
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2498..3032
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3339..3516
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3522..3605
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3610..3716
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 165..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3769 AA; 424664 MW; 33F24323942DAE86 CRC64;
MPLALGEFGE TATALLPRFV SFAHLDRTCP SCCSSCRGCW LLLGNQEEAM KKEGQQARKS
RKLSELDVPF KVKAGQIDKL TLKIPWKNLY GEAVVATLEG LYLLVVPGAS IKYDAEKEEK
SLQDIKQKEL SRIEEALQKA AEKGAHSGEF ICGLENFVYK DIKPEGRKRK KHKKHFKKPF
KGLDRSKDKP KEAKKDTFLE KLATQVIKNV QVKITDIHIK YEDDITDPKR PLSFGVTLGE
LSLLTANEHW TPCILNEAEK IIYKLIRLDS LSAYWNVNCS MSYQESREQI LDHLKSEILT
SIDIPPNHQY IFQPISASAK LYMNPYAETE LKTPKLDWNI EVQNIAIELT KPQYLSIIDL
LESVDYMVRN VPYRKYKPYL PLHTNGRQWW KYAIDSVLEV HVRRYTQMWS WSNIKRHRQL
LKSYKSAYKN KLTQTKVSEE IQKQIQDLEK TLDVFNIILA RQQAQAEVIR SGQKLRKKST
DTGEKRGGWF SGFWGKKESK KKDEESLIPE TIDDLMTPEE KDKLFTAIGY SESTHNLTLP
KQYVAHIMTL KLVSTSITIR ENRNIPETLK IQIIGLGTQV SQRPGAQALK VEAKLEHWYI
TGLRQQDTVP SLVASIGDTA SSLLKIEFET NPENSTADQT LIVQSQPVEV IYDAKTINAV
VEFFQSNKGL DLEQITSATL MKLEEIKERT ATGLTHIIET RKVLDLKINL KPSYLIVPQT
GFYHKKSDLL ILDFGTFQLN SKDQGLQKTS NSSLEEIMDK AYDKFDVEIK SVQLLFARAE
ENWKKCRFQH PSTIHILQPM DFHVELAKAM VEKDIRMARF KVSGGLPLMH VRISDRKMKD
VLCLINSIPL PQKSSVQSPE RQVSSIPIIS DRTEKLLGTS LLLDGVESES DDEYFDAEDG
DIETSKSMKG SERKKVSEAP NEELINLLLK FEIKEVILEF TKQQKEEDTI LVFNVTQLGT
EATVRTFDLT AVSYLKKISL DYHEIQGSKK KPLHLISSSD KPGLDLLKVE YIKADKNGPS
FQTTFEKTEQ TVKVAFSSLN LLLQTQALLS SINYLTTIIP SDGQKMGDTK EVHVSTEKQK
NSALQKVLVP SKDSDVTNFR LFAKLNAFCV SVCEEKNNIA EIKIQGLDSF LSLQSRKQSL
FARLENIIVT DVDSKTVHKK AVSIMGNEVF RFNLDLYPDA TEGDSYTDMS KVDGVVSLNV
GCIQIVYLHK FLMSLLNFLN NFQTAKEALS AATAQAAEKA ATSVKDLAQR SFRVSINIDL
KAPVIVIPQS SISTNAVVID LGLIRVQNHF SLVSGEDYLN PPVIDRMDVQ LTELKLSRTV
IQPGISHPDI QLLHPINLEF SVNRNLAASW YHKVPVVEIK GHLESMNVSL NQEDLNLLFR
ILAENLGEAT EDLNKVKPRI QETGEIKEPL EISISQQDAH ISQGTLTAGV EEIRSVDIIN
VLLNFEIKEV VITLMKKAEK KGRPLHELNV LQLGVEARVK TYDLTAEAYL KKISMRCFEF
TDSKGEPVHI INSSNVTDEP LLKMLLTKAD SDGPEFKTIH DNTKQRLKVS FSSLDLVLHL
EALLSLMGIL SSAVPSSAPS EKESELKPLV EESRNIIVKA VSSNTSQNDV FDLKIIAELN
SFNILVCDQK SDVADIRIHG MDASISVKPK QTDMFARLKD IIVTNVDLLS IHKKAVSILG
DEVFRFQMTL YPDATEGKAY ADMSKVDGKL SLKVGCIQIV YVHKFFMSLL NFLNNFQTAK
EALSAATVQA AERAASSMKD LAQKSFRLLM DINLKAPVII IPQSSVSPNA VIADLGLIRV
ENKFSLVPME HCSLPPVIDK MNIQLTQLKL SRTILQAGLL QHDIEILKPV NMLLSVQRNL
AATWYVQIPG MEIEGKLKPM QVALSEDDLT VLMKILLENL GEASSQPSPT QSTQETVRVR
KDVLSGPDHL KEQEDSVDSK LSMDQNVTLQ FDFHFESLSI VLYNNDVSQE SKLSFHNDSF
RLGELRLHLM ASSGQMFKDG SMNVGIKLRT CTLDDLREGI ERATSRMIDK KNDQDNSSSM
IDISYQQGKN GRSHIDAVLD KLYVCASVEF LMTVADFFIK AMPQRPENMA KEVQVSLRQT
STAKIKIEKD DSVRPHMTLK AKITDPEVVF VANLTKADAP ALTASFQCDL SLSTSKLEQK
MEASVKDLKV LACPFLREKR RKNITTVLQP CSLFMEKHTW DSGKQNINIV FGEFIIKISP
IILNTVMTIM AAMSPKTKED ESKDTSKEIE NLWGVKSVSD YNSWFLGVDV ATEITENFKD
IEHPSIEENC AVVVESIQVT LECGLGHRTV PLLLAESKFS GNIKNWTSLM AAAADMTLEV
HYYNEIHAVW EPLIERVEGK RQWNLRLDVK KNPVQDKNLM PGDDFIFVPE PQTAVHISSA
DTMNITISKS CLSVFNNLAK GFSEGTASTF DYSLKDKAPF TVKNALGVPV KVQTNHNFRL
MGSCEKGDIY DVDVGQNLEL EYAGMEPSCQ GKLSILNRQE SSFFALTFVP HGYTEVAKIP
VARPGRRLYN VRNPNASHSD SVLVQIDATE GNKVITLRSP LQIKNHFSIA FIIYKSVKNV
KLLEPIGVAR PEEEFHVPLD SYRCQLFIQP SGILENQYKE STTYISWKEE LHRSKEVRCM
LQCPSVEVNF LPLIVNTVAL PDELSYINTH GEDWDPAYII HLYPTLTLRN LLPYSLRYLL
EGTAETHELA EGSAADVLHS RISGEIMELV LVKYQGKNWS GHFRICDTLP EFFHVCFSSE
SAEVMTVDLS IHIRRIGSQM VLSLFSPYWL INKTSRVLQY RSEDIHVKHP ADFRDIILFS
FKKKNIFSKN KVQLKISTSA WSSSFSLDTV GSYGCVKCPA NSMEYLVGVS IKMSSFNLTR
IVTLTPFCTI ANKSSLELEV GEIASDGSMP TNKWNYIASS ECLPFWPENL SGKLCVRVVG
CEGSSKPFFY NRQDNGTLLS LEDLNGGILV DVNTAEHSTV ITFSDYHKGS APALIINHTP
WDTLTYQQSG SQEKVELLPR QARLFAWADP TGTRKLTWTY AANIGQHDLL KDECGQFPYD
ANIQIHWVSF LDGRQRVLLF TDDVALVSKA LQAEEMEQPD QEITLSLHSL GLSLVNNEKK
QEVSYIGITS SGVVWEMKPK QKWKTFSQKQ IILLEESYKK YQIARERGWI KLDSNFEVNF
DTVPMEMRLP IRCPIKRDFL SGIQIEFKQS PHQRSLRARL YWLQVDNQLP GAMFPVIFHP
VAPPKSIALD SEPKPFIDVS VITRFNEYSK VLQFKYFMVL IQEMALKVDQ GFLGAIIALF
TPTTDPEAER KRTKLIQQDI DALNTELMET SMTDMSILSF FEHFHISPVK LHLSLSLSSG
GEESDKEKQE MIAIHSVNLL LKSIGATLTD VDDLIFKLAY YEIRYQFYKR DQLMWSVVRH
YSEQFLKQMY VLVLGLDVLG NPFGLLRGLS EGVEALFYEP FQGAVQGCEE FAEGLVIGVR
SLFGHTVGGA AGVVSRITGS VGKGLAAITL DKEYQQKRRE EMGRQPKDFG DSLARGGKGF
LRGVVGGVTG IIKKPMEGAK KEGAAGFFKG IGKGLVGAVA APTGGIIDMA SSTFQGIQRA
AESTEEVSSL RPPRLIHEDG IIRPYDRRES EGYDLFENHI KKLEGETYQY HCAISGSKRT
ILVITNRRVL CIKEVEILNL MCIDWQCPFE DFVSPPSVNG NMLNISVKDQ SLFHKKDSAN
QACLRKIYLQ DTTTAERARH AIEDAQSVRH QQKLMKQSSL KLLRPQMPI
//
