ID L5K4Y8_PTEAL Unreviewed; 478 AA.
AC L5K4Y8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Integrator complex subunit 12 {ECO:0000256|ARBA:ARBA00016814};
DE AltName: Full=PHD finger protein 22 {ECO:0000256|ARBA:ARBA00032277};
GN ORFNames=PAL_GLEAN10022585 {ECO:0000313|EMBL:ELK06387.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06387.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC {ECO:0000256|ARBA:ARBA00011316}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 12 family.
CC {ECO:0000256|ARBA:ARBA00006009}.
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DR EMBL; KB031030; ELK06387.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K4Y8; -.
DR STRING; 9402.L5K4Y8; -.
DR eggNOG; KOG4323; Eukaryota.
DR InParanoid; L5K4Y8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15501; PHD_Int12; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039054; Int12_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13415:SF2; INTEGRATOR COMPLEX SUBUNIT 12; 1.
DR PANTHER; PTHR13415; NUCLEAR FACTOR-RELATED; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 175..231
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 60..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 50539 MW; D9E155427ABF5AED CRC64;
MIELLSCIEY LDEVFTMAAT VNLELDPIFL KALGFLHSKS KDSAEKLKAL LDESLARGID
SSYRPSPKDV EPPKITSTKT ISVKQEPKTS SSLPSGNNNG KVLTTEKVKK EAEKRPADKM
KSDITEGVDI PKKPRLEKPE ARSSPITVQT SKDLAMADLS SFEETSADDF AMEMGLACVV
CRQMTVASGN QLVECQECHN LYHQDCHKPQ VTDKEVNDPR LVWYCARCTR QMKRMAQKTQ
KPPQKPAPAV VSVAPAVKDP LVKKPETKLK QETTFQAFKR TEVKTSAVIS GNSSSTSVSS
SVTSGLTGWA AFGAKTSSAG PSTAKLSSTT QNNSGKPATS SANQKPVGLT GLATSSKGGI
GSKMGSSNNT SPTVPLKPPP PLTLGKTGLS RSVSCDNVSK VGLPSPSSLV PGGSSQLSGN
GNSGTSGPSG STTSKTTSES SGSPSTSLKG PTSQESQLNA MKRLQMVKKK AAQKKLKK
//
