ID   L5K551_PTEAL            Unreviewed;       605 AA.
AC   L5K551;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Aminopeptidase O {ECO:0000313|EMBL:ELK06680.1};
GN   ORFNames=PAL_GLEAN10003703 {ECO:0000313|EMBL:ELK06680.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06680.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB031011; ELK06680.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5K551; -.
DR   STRING; 9402.L5K551; -.
DR   MEROPS; M01.028; -.
DR   eggNOG; KOG1047; Eukaryota.
DR   InParanoid; L5K551; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR033577; AOPep.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR46627; AMINOPEPTIDASE O; 1.
DR   PANTHER; PTHR46627:SF1; AMINOPEPTIDASE O; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Aminopeptidase {ECO:0000313|EMBL:ELK06680.1};
KW   Hydrolase {ECO:0000313|EMBL:ELK06680.1};
KW   Protease {ECO:0000313|EMBL:ELK06680.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          257..335
FT                   /note="Aminopeptidase N-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17900"
FT   DOMAIN          434..531
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
SQ   SEQUENCE   605 AA;  67206 MW;  5421D45610F4DAE9 CRC64;
     MNINLDPSRD DLPLMANTSH ILVKHYVLDL DVNFESQIIE GTIVLFFDSG NKFRKKSSST
     EETCRPESNE ACKFRMLEPC HISVTNTRTF SSKMGYNDFA ICGKGEKDTS GKDGNHDNWK
     LASEISSSKY CCDTGNHGSE DFLLVLDCCD LSVLKVEEVD VAAVPGIEKF TRSPKLTVVS
     ELRNQIVREL VTLPADRWRE QLDCYARCSQ APGCGELLFD TDTWSLQIRK TGAQTAPDFP
     HAIRILYRTK PQGRSVTWTS DQSGRPCVYT MGSPINNRAL FPCQEPPVAM STWQATVRAA
     ASFVVLMSGE NSAKPTQLQE GYSSWHYYVT MPMPASTLTI AVGSWTEMKP ETYSSNDLAA
     ERRSFSPSEA DFRCVGVCGH VEYPCRFQNA SAATQEIIPH RVFAPVCLKH TCQETLLRLI
     PPCLSAAHSV LGTHPFSRLD VLIVPANFPS LGMASPHIVF LSQSTLTGRS HLCGTRLCHE
     IAHSWFGLAI GARDWTEEWL SEGFATHLED VFWAKAQQLA PSEAQEQQEL RAVLRWRRLQ
     DEVRNSPEEM QVLSCLSETS SLGPRSTAVA VATEAFILPP FDYSQVFGIH NQTGGKAAIQ
     ESSPL
//