ID L5K6I9_PTEAL Unreviewed; 461 AA.
AC L5K6I9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma {ECO:0000313|EMBL:ELK06108.1};
GN ORFNames=PAL_GLEAN10023684 {ECO:0000313|EMBL:ELK06108.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06108.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; KB031032; ELK06108.1; -; Genomic_DNA.
DR RefSeq; XP_015450717.1; XM_015595231.1.
DR RefSeq; XP_015450718.1; XM_015595232.1.
DR RefSeq; XP_015450719.1; XM_015595233.1.
DR RefSeq; XP_015450720.1; XM_015595234.1.
DR RefSeq; XP_015450721.1; XM_015595235.1.
DR RefSeq; XP_015450722.1; XM_015595236.1.
DR AlphaFoldDB; L5K6I9; -.
DR STRING; 9402.L5K6I9; -.
DR GeneID; 102891637; -.
DR KEGG; pale:102891637; -.
DR eggNOG; KOG4637; Eukaryota.
DR InParanoid; L5K6I9; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ELK06108.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transferase {ECO:0000313|EMBL:ELK06108.1}.
FT DOMAIN 65..160
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 358..452
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 181..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 54391 MW; 7F8064ADC68F6381 CRC64;
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPVTSAVT NGMKDSSVSL
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG
KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SKYQQDQLVK EDNIDAVGKK
LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQYSKEY
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKKQALDNRE IDKKMNSIKP
DLIQLRKIRD QHLVWLNHKG VRQKRLNTWL GIKNEDADET YFINEEDENL PHYDEKTWFV
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN
LYGSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPSLC R
//
