ID L5K796_PTEAL Unreviewed; 459 AA.
AC L5K796;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Interleukin-7 receptor subunit alpha {ECO:0000256|ARBA:ARBA00018930};
GN ORFNames=PAL_GLEAN10001734 {ECO:0000313|EMBL:ELK07584.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK07584.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Receptor for interleukin-7. Also acts as a receptor for
CC thymic stromal lymphopoietin (TSLP). {ECO:0000256|ARBA:ARBA00025125}.
CC -!- SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP
CC receptor is a heterodimer of CRLF2 and IL7R.
CC {ECO:0000256|ARBA:ARBA00025831}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
CC subfamily. {ECO:0000256|ARBA:ARBA00008280}.
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DR EMBL; KB030952; ELK07584.1; -; Genomic_DNA.
DR RefSeq; XP_006917863.1; XM_006917801.2.
DR AlphaFoldDB; L5K796; -.
DR STRING; 9402.L5K796; -.
DR GeneID; 102889092; -.
DR KEGG; pale:102889092; -.
DR CTD; 3575; -.
DR eggNOG; ENOG502S4WE; Eukaryota.
DR InParanoid; L5K796; -.
DR OrthoDB; 4143009at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.1870; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR040997; FN3_7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF27; INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF18447; FN3_7; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK07584.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..459
FT /note="Interleukin-7 receptor subunit alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003968838"
FT TRANSMEM 241..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..232
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 331..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 51622 MW; 26CB2FAD871B781E CRC64;
MTILGTAFGM VFYLLQVVSG ESGYAQNGDF EDAELDDYSF SCYSQLEVNG SQHLLNCTFD
DPDVNSTDLE FEICEALVGV NCLNFSKHQE MYLIKTNKFL LIGDSKICVK LGGKIVTCRK
MKIVNIVKPE APFDIRVIYR KEANDFVVTF NTSHLQKNYV KKLIHEVAYR QEKNENDWMR
VNLSSTKLTL LQRKLQPDAK YEIKVRSIPN TDYFKGFWSE WSPSFHFRTP ETKGSEEMDP
VLLIVSVLSF FSVALIVILA CVLWKKRIKP IIWPSLPDHK KTLEQLCKKP KKNLNASFSP
ESFLDCQIHK VDGIQARDEV EGFLQDAFAP QPAEPEKQRP GAGGQGSSWM SEQAVKTSQT
FRGDAPLRCQ AGDVSACDPP VLSSSRFPDC REGDEKGPHA YQGLLLGPGT TNDTVSPPFP
FQSEILTLTP AMQAQPLLTS LGSNQEEAYV TMSSFYQNQ
//
