ID L5K7P2_PTEAL Unreviewed; 401 AA.
AC L5K7P2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN ORFNames=PAL_GLEAN10000346 {ECO:0000313|EMBL:ELK06806.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK06806.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Probable chloride channel. May be involved in cell adhesion.
CC {ECO:0000256|ARBA:ARBA00037608}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361114}.
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DR EMBL; KB030995; ELK06806.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K7P2; -.
DR STRING; 9402.L5K7P2; -.
DR eggNOG; KOG4433; Eukaryota.
DR InParanoid; L5K7P2; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF5; PROTEIN TWEETY HOMOLOG 1; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 2.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 343..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 378..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 401 AA; 43738 MW; 3A2F4076DCC3DE9E CRC64;
MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SGFAPQEREY QQALLLVVAL AGLGLGLSLI
LIAAYLIRVC CCQPPGPPSA KSPPPGGGCV TWSCIAALLI GCAGIGIGFY GNSETSDGVS
QLSSALLHAN HTLSAIDHLV LETVERLGEA VRTELTTLEE VLTQRTELVA ATRGARRQAE
AVTQQLQGLA FWQGVPLSPL QVAEDVSFVE EYRWLAYVLL LLLQLLVCLF TLLGLAKQSK
WLVIILEWAG GVHHWVLFPP AFPQRLTLSQ RALANIHSQL QGLEREAVPQ FPSAQKPLLS
LEETLNVTEG NFHQLVALLH CRGLHKDYGA ALRGLCEDVL EGLLFLLLFS LLSAGALATA
LCSLPRAWAL FPPSDDYDDT DDDDPFNPQE SKRFVQWQSS I
//
