ID   L5K8T9_PTEAL            Unreviewed;       507 AA.
AC   L5K8T9;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Ataxin-10 {ECO:0000256|ARBA:ARBA00018804};
GN   ORFNames=PAL_GLEAN10007143 {ECO:0000313|EMBL:ELK07915.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK07915.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- FUNCTION: Necessary for the survival of cerebellar neurons. Induces
CC       neuritogenesis by activating the Ras-MAP kinase pathway. May play a
CC       role in the maintenance of a critical intracellular glycosylation level
CC       and homeostasis. {ECO:0000256|ARBA:ARBA00002116}.
CC   -!- SIMILARITY: Belongs to the ataxin-10 family.
CC       {ECO:0000256|ARBA:ARBA00008384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB030944; ELK07915.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5K8T9; -.
DR   STRING; 9402.L5K8T9; -.
DR   eggNOG; KOG2676; Eukaryota.
DR   InParanoid; L5K8T9; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR019156; Ataxin-10_domain.
DR   PANTHER; PTHR13255; ATAXIN-10; 1.
DR   PANTHER; PTHR13255:SF0; ATAXIN-10; 1.
DR   Pfam; PF09759; Atx10homo_assoc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          370..460
FT                   /note="Ataxin-10"
FT                   /evidence="ECO:0000259|Pfam:PF09759"
SQ   SEQUENCE   507 AA;  57287 MW;  8079294E3E5A5621 CRC64;
     MAAPRQLPAR VSGIMVPASI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSSHA
     VERACRDPSQ VDDLASSLQL ITECFRCLRN ACIECFVNQN SIRNLDAVCI AVDLIFLFRE
     LRVEQESLLT AFRCGLQFLG NIASRNEASQ SAVWLHAFPE LFLSCLNHPD KKIVSYSSMI
     LFTSLNSARM KDLEENLNIA INVVEAHYKQ PESEWPFLII TDHFLKSPEL VKAMYAKMSN
     QERVTLLDII IAKVMADEPL TKEEIPVFLS HAELFASTFV DQCRLVLKLT SEQYTDDEEA
     LATIRLLDVL CEMSVHGDLL GYLQAYPGLL DRVVDLLRLI HVTGTDTTNI FSACSYIKAD
     SNISNMAEGF KSHLIRLIGN LCYKNRVNQD KVNEMDAIHL ILDNCSPDDR NPFMTQWVVY
     TIRNLTEDNT QNQDLIANME EQGLVDASLL KKMGFEVEKR GDKLILKSIH DAPQPVLGRV
     ITEPCPFGIE RGERGLRAIN TSRAKSP
//