ID L5KB67_PTEAL Unreviewed; 340 AA.
AC L5KB67;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Platelet-derived growth factor subunit B {ECO:0000256|ARBA:ARBA00018117};
DE AltName: Full=PDGF-2 {ECO:0000256|ARBA:ARBA00031888};
DE AltName: Full=Platelet-derived growth factor B chain {ECO:0000256|ARBA:ARBA00032481};
DE AltName: Full=Platelet-derived growth factor beta polypeptide {ECO:0000256|ARBA:ARBA00032702};
GN ORFNames=PAL_GLEAN10007276 {ECO:0000313|EMBL:ELK08011.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08011.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR EMBL; KB030944; ELK08011.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KB67; -.
DR STRING; 9402.L5KB67; -.
DR eggNOG; ENOG502S2VW; Eukaryota.
DR InParanoid; L5KB67; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR006782; PDGF_N.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF2; PLATELET-DERIVED GROWTH FACTOR SUBUNIT B; 1.
DR Pfam; PF00341; PDGF; 1.
DR Pfam; PF04692; PDGF_N; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU003818};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 180..284
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 162..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..330
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 37562 MW; 19544358C7591DC6 CRC64;
MLAVISCQVW SLSGCGASQN LLYDGGNGCT QSNLRASWGS YWEAETQHLS WVIGKFWPSG
LCAPGVCLLP TPSLAVHLSV AGGGPAGIFH RRECLCRGEE GQGWEALPPS SLGSTVSTWQ
GDPIPEELYE MLSDHSIRSF DDLQRLLHGD SVDEDGAELD LNLTRSHSGG KPESLSRGRR
SLDSPTVAEP AMIAECKTRT EVFEISRRLV DRTNANFLVW PPCVEVQRCS GCCSNRNVQC
RPTQVQLRHV QVRKIEIVRK KPSFKKATVT LEDHLACKCE TVVAARPVTR SPGSSQEQRA
KTPQTRMSVR MVRVRRPPKG KHKKFKHTHD KKALKETLGA
//
