ID L5KD68_PTEAL Unreviewed; 270 AA.
AC L5KD68;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Disintegrin and metalloproteinase domain-containing protein 2 {ECO:0000313|EMBL:ELK08741.1};
GN ORFNames=PAL_GLEAN10021555 {ECO:0000313|EMBL:ELK08741.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08741.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB030862; ELK08741.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KD68; -.
DR STRING; 9402.L5KD68; -.
DR eggNOG; KOG3607; Eukaryota.
DR InParanoid; L5KD68; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF108; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068};
KW Integrin {ECO:0000313|EMBL:ELK08741.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 28..117
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DISULFID 89..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
SQ SEQUENCE 270 AA; 29347 MW; 5ADBA6FB2E3BDE17 CRC64;
MEDFAHFISK PKSQCLQNQP RLDPSYKAAV CGNKQVEEGE QCDCGTQEEC EALPDTCCGS
TACVLKQGNT CDSGDCCEHC QFKAKGDTCR ASLDECDLPE FCNGSSASCQ DNVFIHNGYP
CGEKQWLCLD GSCVSGKKQC VEIFGEVNNK HARKLTRTNE LPRTPSEKQI MLICPSVSTK
EFTKQYKFTR NEPAVQKRMR SCLVVFPLPC PVAAAQPNRI PKGELARTEN NCSSYPGSLA
QCAVHLSTSA REPQSCPTAF SVGGASCALA
//
