ID L5KD86_PTEAL Unreviewed; 1847 AA.
AC L5KD86;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
GN ORFNames=PAL_GLEAN10010683 {ECO:0000313|EMBL:ELK09307.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09307.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR EMBL; KB030834; ELK09307.1; -; Genomic_DNA.
DR STRING; 9402.L5KD86; -.
DR eggNOG; KOG1037; Eukaryota.
DR InParanoid; L5KD86; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd01437; parp_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR031273; PARP4.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU362114};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 128..221
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 361..496
FT /note="PARP alpha-helical"
FT /evidence="ECO:0000259|PROSITE:PS51060"
FT DOMAIN 495..699
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT DOMAIN 733..861
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 1002..1169
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 55..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1553..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1847 AA; 204085 MW; A45150695F748D62 CRC64;
MLSKASPWPP GKDRTIDGAL DLQRKIMETF KWQHHHPLFP NSDSGVTLIA HILPGRRNRK
TPPPGAGAER DSPQRPSQKC PRSGIPGGGR GSGPPTGSRL ASSPQPESRR RKRREQRESG
GAGSSGRMTM GVFANCTFCL NIKHLPRQQK KKLQTDIQEN GGNVSFILNS QCTHIISDSA
GDLSKYHLNY IQKNHIHIAN PDFIWESIKE RRLLDVKNYS PNKSLDSTLP LYQGASSSEV
KTDDGCLDNS AETGGVELTK FYTENVEIPH FPQDFEVAKY NALEKVGTEG VQDIAVLELQ
CPQDPGHPTF RISACFHPTG VTETRRQFLV RPTSADASEC YENYIEELKK QGFQLREHFT
PEATQLASGK LQAWLLEEDI RSSALSQEVS DLVEMVWAEA LGHLEHTLLT PANRISLNDV
SKAEGILLHV KAALKSGETE EQLQKMMSEF YRLIPHRGST TEEVNLRLLA KKEDLCQLIR
DMANVNETNL SKRNPPSLAK YRALRCKIEH VEQNTEEFFR VRKEVLQNNR SQSPVDILQI
FRVGRASETT AFLSQLGNVT SLLHGSPVRS FVGILSRGLL LPKVVEDRGV TRTDVGNLGS
GIYFSDSLST STKYSHPGDT DGTRLLVVCD VALGKCLDLH KKDFSLTEAP PGYDSVHGVP
GTATVTTDFE DDEFVVYKTN QIKMKYIIKF CLPGDEIKDF HPCNNIELEE YTPEISNFPT
VEDYRLPDSG PSSSLGAGLQ DASGNSVPLE DVCIKGKIID FVAQVIVFQT YTNQSHVPIE
AKYVFPLDDK AAVCGFEAFI NGKHIVGEIK EKEAAHQEYR EAISQGHGAY LMDQDAPDVF
TVSVGNLPPK AKVLIKITYI TELSIQGTVA VFFMPATVAP WQQDKALNEN IQDTVKKISI
KEIGSKQSFS LTMSIEMPYV IEFISSDTHE LKKKSTDCKA VISTVEGSTL DSSGFSLRVG
LTDAHLPRMW VEKHPEKESE ACMLVFHPDL GSAFSDTAER SEVVICLDCS SSMEGVTFLH
AKQIALYALS LVGMEQKVNV IRFGSGYQEL FSYPKCLTSD SVAAEFITSA SPTMGSTDFW
KVLRYLSLLP PSQELRNVLL ISDGHLQSDS LTLQLVKRHV QHTRLFSCGV GSTANRHLLR
TLSQHGVGAF EYFNSKSKYS WKKQIEDQMT RSRSPSCHSV SVTWQRLSPE APEPLQAPAQ
VQALFHGDRL LVYGFIPHCT QATLRALTQE EEFSTMVSTT ELQKTTGTMI HKLTARALIR
DYEDGILHDD ETNHEMKKQV LKSLIIQLSK ENCLITQFTS FVAVEERDGN ESPFPNTPNI
LELVAKDVDI LPYMSWQEVQ PCGFNAPCGS AWQPLSASSD WHGEFHLSKR KQKPSTVEVF
GVLEGLSLAS KAPEKHFRSG WKCTHAETPL DLSQMEPRTC KGAGTPLATA ISPQMAVCRS
FATPRPAASP AALGSVSFSH PCPPREPPHS SLFSFCSAEL SGPATSDLIP EAGCSINVFP
EQDSALRGLP PNPPVESFIG PAFAGGLFGS RQCSLPTNYK GLQALGNAGT FLEVDSSPQP
SPPFSSPSLS PPFSAADSTL LPPSDFSTFN FLESATPLST SYMQPAHLLG LGYHGYGASP
SNLPARNAVS RQGLRSAVPR SFGTENDETR GFLRITPFKK VAKSHVAGRE FTASSQAWEN
QGPGICQQSQ RSSVPWTGLF RLQTEDGFWK LTPELGVILN LNIDILNSFL EQKGILSLGV
KGRERLLDLI ATFLVLQFLR TQLEQKGIVF KSLMKLDDAA VSRDIPWASE KIKKASEWVR
RTEGQYPSIC QRLELGKDWD SATKQLLRLQ PVNTTSPLHR VLNYGQG
//
