ID   L5KDT0_PTEAL            Unreviewed;       776 AA.
AC   L5KDT0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Homeobox protein SIX4 {ECO:0000313|EMBL:ELK09834.1};
GN   ORFNames=PAL_GLEAN10009868 {ECO:0000313|EMBL:ELK09834.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09834.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
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DR   EMBL; KB030790; ELK09834.1; -; Genomic_DNA.
DR   RefSeq; XP_006915160.1; XM_006915098.2.
DR   AlphaFoldDB; L5KDT0; -.
DR   STRING; 9402.L5KDT0; -.
DR   GeneID; 102895762; -.
DR   KEGG; pale:102895762; -.
DR   CTD; 51804; -.
DR   eggNOG; KOG0775; Eukaryota.
DR   InParanoid; L5KDT0; -.
DR   OrthoDB; 5317763at2759; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR   PANTHER; PTHR10390:SF36; HOMEOBOX PROTEIN SIX4; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          226..277
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        228..278
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..302
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  82631 MW;  CBC510C4048AFB1F CRC64;
     MSSSSPTGQI ASAADIKQEN GMESASEGQE APREVAGGAA AGLSPPAPAP FPLEPGDAAA
     AAARVSEEEG AVAAAAVDQV QLHSELLGRH HHAAATAAQT PLAFSPDHVA CVCEALQQGG
     NLDRLARFLW SLPQSDLLRG NESLLKARAL VAFHQGIYPE LYSILESHSF ESANHPMLQQ
     LWYKARYTEA ERARGRPLGA VDKYRLRRKF PLPRTIWDGE ETVYCFKEKS RNALKELYKQ
     NRYPSPAEKR HLAKITGLSL TQVSNWFKNR RQRDRNPSET QSKSESDGNP STEDESSKGH
     EDLSPHPLSS SSDGVTNLSL SSHMEPVYMQ QIGNAKILSS SGVLLNGSLV PASTSPVFLN
     GNSFIQGPNG VILNGLNVGN TQTVSLNPPK MASNIVSNGI SMTDILGTTS QDVKEFKVLQ
     SSSANSAATT SYSPSAPVSF PGLIPSTEVK REGIQTVASQ EGGSVVTFTT PVQINQYGIV
     QIPNSGANSQ FLNGSIGFSP LQLPPVSVAA SQGSISVNSS TSDGSTFTSE STTVQQGKVF
     LSSLAPSAVV YTVPNSGQTI GSVKQEGLER SLVFSQLMPV NQNAQVNTNL SSENISGSGL
     HPLASSLVNV SPTHNFSLTP PSLLNPTELN PDIADSQPMS APVTSKSTVT SVGNTNYATL
     QNCSLIAGQD LLSVPMTQAA LGEIVPTAED QVGHSSPAVH QDFVREHRLV LQSVANIKEN
     FLNSESKATS NLMMLDSKSK YVLEGMVETV CEDLETDKKE LAKLQTVQLD EDMQDL
//