ID   L5KEA8_PTEAL            Unreviewed;       935 AA.
AC   L5KEA8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Sorting nexin-25 {ECO:0000313|EMBL:ELK08838.1};
GN   ORFNames=PAL_GLEAN10021666 {ECO:0000313|EMBL:ELK08838.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK08838.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; KB030862; ELK08838.1; -; Genomic_DNA.
DR   STRING; 9402.L5KEA8; -.
DR   eggNOG; KOG2101; Eukaryota.
DR   InParanoid; L5KEA8; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06878; PX_SNX25; 1.
DR   CDD; cd08720; RGS_SNX25; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037899; SNX25_PX.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          137..303
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          426..540
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          603..723
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          551..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   935 AA;  107640 MW;  B15CDDC0B9292730 CRC64;
     MXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXGGSW RVPVAVAALS ALSLSYLGPG
     CWQDAGGAGP CTILLRLSLY LGCAAAAFLL GTLFSLVCRS PRAPPPDFAA AWRHLAAASP
     GYGNSHESVQ SRRVVISHNM DKVLKEVFDY SYRDYIQSWY GNLSKDEGQL YHLLLEDFWE
     IARQLHHRLS HVDVVKVVCN DVVRTLLTHF CDLKAANARQ EEQLRPFVLH ACLRNSDEEV
     RFLQTCARVL VFCLLPSKDI QSLSLHIMLA EILTTKVLKP VVTLLSNPDY INRMLLAQLE
     HREQMNEHHK RAYTYAPSYE EFIKLINSNS DVDFLKQLRY QIVVEIIQAT TISSFPQLKR
     HKGKETAAMK ADLLRARNMK RYINQLTVAK KQCEKRIRTL GGPAYDQQED GALEEGEGPQ
     NQKILQFEDI LANTFYREHF RMYMERMDKR ALISFWESVE YLKNANKNEI PQLVGEIYQN
     FFVESKEISV EKSLYKEIQQ CLVGNKGIEV FYKIQGDVYE ILKDRYYPSF IVSDLYEKLM
     IKEEEKHVSQ LISHKDEADP GGEAGEESVD EGTSQISEQA SFAVNKLREL NEKLEYKRQA
     LNSIQNAPKP DKKVTEENGE QMPCYFVMVS LQEVGGVETK NWTVPRRLSE FQNLHRKLSE
     CFPSLKKVQL PSLSKLPFKS VDQKFMEKSK NQLNKFLQNL LSDERLYQSE ALYAFLSPSP
     DYLKVIDVQG KKSTFSLSSF LERLPRDFFC HQEEEIEEDS DLSDYGDDVD GRKDALAEPC
     FMLIGEIFEL RGMFKWVRRT LIALVQVTFG RTINKQIRDT VNWIFSEQMF VYYITVFRDA
     FWPHGKLAPP TKIRSEEESQ ETKQRAQQKL LENIPDMLQS LVGQQNARHG IIKIFNALQE
     TRANKHLLYV LMELLLIELC PELRAHLDQL KAGQV
//