ID L5KEE7_PTEAL Unreviewed; 1108 AA.
AC L5KEE7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=T-lymphoma invasion and metastasis-inducing protein 2 {ECO:0000313|EMBL:ELK09915.1};
GN ORFNames=PAL_GLEAN10013151 {ECO:0000313|EMBL:ELK09915.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09915.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030789; ELK09915.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KEE7; -.
DR STRING; 9402.L5KEE7; -.
DR eggNOG; KOG3519; Eukaryota.
DR InParanoid; L5KEE7; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF5; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00455; RBD; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 524..638
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 852..925
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 934..1020
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 291..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 121990 MW; 4BAD6AA8348774B6 CRC64;
MSLSGDPSSG LSSFPLLTWQ DFVLELQRHL FGQLILDERV VTLSVIPTAL RDILCITGSF
TPFTEKSFWD GRMDLIPIED CLRFVSPVPD KRQTMEGNRK TADGLYLASA KVKMGNSESQ
YTFQGSKNHS NTIPGAKQKP CSLKIRSIHA KDDKSLHGWG HASSGAGYKS RSLARSCLSH
FKSNQPYASR LGGPACKVSK GNAYSKHRTN GSGSDFQGNH AAFLPENGFH YVAQDRAENH
VASKDCNGHL LNCYGRNESA ASTPPGEDRR SPRVLIKTLG KLDGCLRVEF HSGGAHGHRP
GPPAGTEGAP GSSLSSLREL DPDAPLAGLA ASGVRLSDED IGAPASLSHR VSFASDMDMP
SRVGHREPGP YASFTLPCRR SKAFTEDASK KDTLKARMRR ISDWTGSLSR KKRKLQEPRS
KEGSDYFDSR SDGLNVDGQG PFQASAALWS GGSAQLLSQR SESAHAIGSD PLRQDIYENF
MRELEIGRTN TEHAETSTET AESSSESLSS LEQLDLLFEK EQGVVRKAGW LFFKPLVTLQ
KERKLELVAR RKWKQYWVTL KGCTLLFYET YGKHSLDQSG APRCALFAED SIVQAVPEHP
KKEHVFCLSN SFGDVYLFQA TSQTDLENWV TAIHSACASL FAKKHGKEDT VRLLKNQTKN
LVQKIDIDSK MKKMAELQLS VVRDPKNRKA IENQIQQWEQ NLEKFHMDLF RMRCYLASLQ
GGELPNPKSL LAATSRPSKL ALGRLGVLSV SSFHALVCSR DDSAFRKRTL SLTQRGRNKK
GIFSSLKGLD TLARKGKEKR SSITQIFDSS GSHGFSGTQL PQNPNNSSKV DDLLHMYGSA
VDGVPRDSTW EVQTYVHFQD NQEVSVTIKP EHRVEDILTL ACKMRQLEPS HYGLQLRKSV
DENTEYCIPA PYEYMQEQAS VYDEIEVFPL NVYDVQLTKT GGVSDFGFAV TAQVDGHQHL
SRIFVSDVLP HGLAYGEGLR KGNEIMTLNG EAVSDLDLKQ MEALFSEKSV GLTLIARPPD
TKGTLCTSWS DSDLFSRDQK SLLPPPNQSQ LLEEFLDNFK KNTANGGLAG AWHCLSTAAL
PAGPSATVVP TSAGPSLEAA SRQPGGSH
//
