ID L5KG38_PTEAL Unreviewed; 249 AA.
AC L5KG38;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Natriuretic peptides A {ECO:0000256|ARBA:ARBA00020078};
DE AltName: Full=Atrial natriuretic factor prohormone {ECO:0000256|ARBA:ARBA00031619};
DE AltName: Full=Atrial natriuretic peptide prohormone {ECO:0000256|ARBA:ARBA00032736};
DE AltName: Full=Atriopeptigen {ECO:0000256|ARBA:ARBA00031144};
DE AltName: Full=Cardiodilatin {ECO:0000256|ARBA:ARBA00030903};
DE AltName: Full=preproCDD-ANF {ECO:0000256|ARBA:ARBA00033220};
GN ORFNames=PAL_GLEAN10012987 {ECO:0000313|EMBL:ELK10515.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK10515.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Hormone produced in the kidneys that appears to be important
CC for maintaining cardio-renal homeostasis. Mediates vasodilation,
CC natriuresis and diuresis primarily in the renal system, in order to
CC maintain the extracellular fluid volume and control the fluid-
CC electrolyte balance. Specifically binds and stimulates cGMP production
CC by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may
CC be the natriuretic peptide responsible for the regulation of sodium and
CC water homeostasis in the kidney. {ECO:0000256|ARBA:ARBA00002857}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of diuresis and inhibiting aldosterone synthesis. In vitro,
CC promotes the production of cGMP and induces vasodilation. May promote
CC natriuresis, at least in part, by enhancing prostaglandin E2 synthesis
CC resulting in the inhibition of renal Na+-K+-ATPase. May have a role in
CC potassium excretion but not sodium excretion (natriuresis). Possibly
CC enhances protein excretion in urine by decreasing proximal tubular
CC protein reabsorption. {ECO:0000256|ARBA:ARBA00003298}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of natriuresis and vasodilation. In vivo promotes
CC natriuresis and in vitro, vasodilates renal artery strips.
CC {ECO:0000256|ARBA:ARBA00002352}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of natriuresis and vasodilation. In vivo promotes
CC natriuresis. In vitro, selectively vasodilates intestinal and vascular
CC smooth muscle strips. {ECO:0000256|ARBA:ARBA00003360}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of natriuresis and vasodilation. In vivo promotes
CC natriuresis. In vitro, selectively vasodilates intestinal smooth muscle
CC but not vascular smooth muscle strips. {ECO:0000256|ARBA:ARBA00002948}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of natriuresis, diuresis, and vasodilation. In vitro,
CC promotes the production of cGMP and induces vasodilation. May promote
CC natriuresis, at least in part, by enhancing prostaglandin E2 synthesis
CC resulting in the inhibition of renal Na+-K+-ATPase. However reports on
CC the involvement of this peptide in mammal blood volume and blood
CC pressure homeostasis are conflicting; according to a report it is not
CC sufficient to activate cGMP and does not inhibit collecting duct
CC transport nor effect diuresis and natriuresis. Appears to bind to
CC specific receptors that are distinct from the receptors bound by the
CC atrial natriuretic and long-acting natriuretic peptides. Possibly
CC functions in protein excretion in urine by maintaining the integrity of
CC the proximal tubules and enhancing protein excretion by decreasing
CC proximal tubular protein reabsorption. {ECO:0000256|ARBA:ARBA00002727}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of natriuresis, diuresis, vasodilation, and inhibiting
CC aldosterone synthesis. In vitro, promotes the production of cGMP and
CC induces vasodilation. May promote natriuresis, at least in part, by
CC enhancing prostaglandin E2 synthesis resulting in the inhibition of
CC renal Na+-K+-ATPase (By similarity). However reports on the involvement
CC of this peptide in mammal blood volume and blood pressure homeostasis
CC are conflicting; according to a report, in vivo it is not sufficient to
CC activate cGMP and does not inhibit collecting duct transport nor effect
CC diuresis and natriuresis (By similarity). Appears to bind to specific
CC receptors that are distinct from the receptors bound by atrial
CC natriuretic peptide and vessel dilator. Possibly enhances protein
CC excretion in urine by decreasing proximal tubular protein reabsorption.
CC {ECO:0000256|ARBA:ARBA00024972}.
CC -!- FUNCTION: May have a role in cardio-renal homeostasis through
CC regulation of regulation of natriuresis and vasodilation. In vivo
CC promotes natriuresis. In vitro, vasodilates intestinal smooth muscle
CC but not smooth muscle strips. {ECO:0000256|ARBA:ARBA00003244}.
CC -!- SUBUNIT: Homodimer; disulfide-linked antiparallel dimer.
CC {ECO:0000256|ARBA:ARBA00011384}.
CC -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
CC Perikaryon {ECO:0000256|ARBA:ARBA00004484}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003686}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC {ECO:0000256|ARBA:ARBA00009041, ECO:0000256|RuleBase:RU003686}.
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DR EMBL; KB030727; ELK10515.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KG38; -.
DR STRING; 9402.L5KG38; -.
DR eggNOG; ENOG502S9RQ; Eukaryota.
DR InParanoid; L5KG38; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:UniProtKB-KW.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR InterPro; IPR002407; Natriuretic_peptide_atrial.
DR PANTHER; PTHR14066; ATRIAL NATRIURETIC FACTOR PRECURSOR; 1.
DR PANTHER; PTHR14066:SF2; NATRIURETIC PEPTIDES A; 1.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00711; ANATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|RuleBase:RU003686}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..249
FT /note="Natriuretic peptides A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969117"
FT REGION 66..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 27108 MW; 2719096684AF3E90 CRC64;
MGSFSTITTS FLLLLVLQLP GQTSANPLYS SVSNADLMDF KNLLDHLEDK MPLEDEVVPP
QVLSEQNEEA EAALSPLPEV PPWTGEVSPA QRDGGTLGRG PWDSSDRSAL LKNKLRALLA
APRSLRRSSC FGGRMDRIGA QSGLGCNSFR VRESGDGMWK RDGEKGNRGF IEAYALSKNT
SRGYVQQQRD QHRSLLPWKF LPQLGGGPMN HGTMTSFLAT ACRVSAEGKI TAMSTGNLKC
SWAKSPSYS
//
