ID L5KKX3_PTEAL Unreviewed; 848 AA.
AC L5KKX3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8 {ECO:0000313|EMBL:ELK11972.1};
GN ORFNames=PAL_GLEAN10015648 {ECO:0000313|EMBL:ELK11972.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK11972.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; KB030666; ELK11972.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KKX3; -.
DR STRING; 9402.L5KKX3; -.
DR eggNOG; KOG3557; Eukaryota.
DR InParanoid; L5KKX3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:ELK11972.1};
KW Receptor {ECO:0000313|EMBL:ELK11972.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:ELK11972.1}.
FT DOMAIN 557..616
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 229..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..672
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 94729 MW; 6D45EC8D364FB541 CRC64;
MAFLVSLSVN SFGVDFSPRN IWVKVTMNGH ISNHPSGFGI YPSQMNGYGT SSTFSQMDRE
HSSKPSAKAL YEQRKNYARD SISSVSNTTH YHVEHLTTFV LDRKDAMITI DDGIRKLKLL
DAKGKVWTQD MLLQVDDRAV SLIDLESKNE LENFPFNTIQ HCQAVMHSCN YDSILALVCK
EPTQNKPDLH LFQCDEVKAN LISEDIESAI SDSKGGKQKR RPDALRVISN ADHGIPPPPR
APAPVPPGTV TQVDVRSRVA AWSAWAADQG DFEKQRQYHG HEETPEMMAA RIDRDVQILN
HILDDIEFFI TKLQKAAEAF SELSKRKKTK KGKRKGPGEG VLTLRAKPPP PDEFIDCFQK
FKHGFNLLAK LKSHIQNPSA ADLVHFLFTP LNMVIQATGG SELASSVLSP LLTKDTIDFL
NYTVNTDERQ LWMSLGETWM KPRAEWPKEQ FIPPYVPRFR NGWEPPMLNF MGAPVEQDIY
QLVGSVAGAA EQHRHETKRY ATEQSSVLEY APPPPDGYAF NNIYTRGTHL DQGEAAVAFK
PAPNRHVDRN YDPLITQPKK YAKSKYDFVA RNGSELSVLK DDILEILDDR KQWWKVRNAS
GNSGFVPNNI LDIVRPTESG VGRADPPYTH TIQKQRMEYG PRSTDPPSAP SPPPTPAPVP
VPLPPSIPAP VPVSKVPANV TRQNSSSSDS GGSTVRDSQR HKQLPVDRRK SQMEEVQDEL
IHRLTIGRSA AQKKFHVPRQ NVPVVNITYD STPEDVKTWL QSKGFNPMTV NSLGVLNGAQ
LFSLNKDELK TVCPEGARVF NQITVQKAAL EDISGSSELQ EIMRRRQEKI SAAASDSGVE
SFDEGSSH
//
