ID L5KL93_PTEAL Unreviewed; 664 AA.
AC L5KL93;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Serine/threonine-protein kinase/endoribonuclease IRE2 {ECO:0000313|EMBL:ELK12097.1};
GN ORFNames=PAL_GLEAN10004943 {ECO:0000313|EMBL:ELK12097.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12097.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KB030664; ELK12097.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KL93; -.
DR STRING; 9402.L5KL93; -.
DR InParanoid; L5KL93; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF15; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ELK12097.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..664
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969256"
FT DOMAIN 258..519
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 522..650
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 161..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 72518 MW; 5F63190416121137 CRC64;
MEIAAGGSSR WPPLALQLQL AALLGTLAPQ AQTLRPESLL LVSTLDGSLH ALSKQTGDLK
WTLKDDPAIQ GPTYVTEMTL YVGKDEAGFY VSKALVHTGV ALVPRGLTLA SMDGPTTDEV
TLQVSGEREG SPSTAVRYPS GSVALPSQWL LIGHHEPPPV LHTTMLRVHP TPGSGTPETR
PSASMQPPAL FTEQQQQQLA EKQQQAPLKP AHPPLNSQNV PSQPSGVTPQ DKKRLQSPSE
PTEDPEAEQL TVVGKISFNP RDVLGRGAGG TFVFRGQFEG RAVAVKRLLR ECFSLVRREV
ELLQESDRHP NVLRYFCTER GPQFHYIALE LCRASLQEYV ENPELDRWGL EPVTALQQLT
SGLAHLHSLH IVHRDLKPAN ILISGPDSQG QGRVVLSDFG LCKKLPAGHC SFSLHSGVPG
TEGWMAPELL QLQPPESPTS AVDVFSAGCV FYYVLSGGGH PFGESLYRQA NILAGAPRLA
HLEEEAHDQV VARSLVEAML SPLPQARPSA PQMLAHPFFW SRAKQLQFFQ DVSDWLEKEP
EQAPLVVALE AGGSAVVRGD WHKHISAPLQ TDLRRFRTYQ GTSVRDLLRA VRNKRHHYRE
LPAELRQALG HVPDGFIQYF TARFPRLLLH THQAMSSCAS ESLFRPYYPP AAGAGGPSLG
AAGS
//
