ID L5KLC1_PTEAL Unreviewed; 294 AA.
AC L5KLC1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Putative short chain dehydrogenase/reductase family 42E member 2 {ECO:0000313|EMBL:ELK12122.1};
GN ORFNames=PAL_GLEAN10004977 {ECO:0000313|EMBL:ELK12122.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12122.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KB030664; ELK12122.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KLC1; -.
DR STRING; 9402.L5KLC1; -.
DR InParanoid; L5KLC1; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 25..119
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT DOMAIN 120..225
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 31908 MW; C646C45F6A2CECFF CRC64;
MTAPPTAAPQ KSEATSVQAP RQKVLVTGGG GYLGFSLGSS LAKSGTSVIL LDLRKPQWEL
SPGTEFIQAD VRDEEALVRA FEGVDCVFHV ASHGMSGAEK LQKEQIESVN VGGTKLVIDG
GGTLRTCVLR PPGIYGPEEQ RHLPRVAGHI RKRLFLFRFG DRGTRMNWVH VRNLVQAHVL
AAEALTAARG YVASGQAYYI NDGESVNIFE WMAPLFEKLG YSQPWIQVPT SWVYLAAALM
ENVHLALRPI CSLPPLLTRS EVSGPLLGEP CTLVPPRPPS RPFATPSCHI PSPL
//
