ID L5KM29_PTEAL Unreviewed; 1091 AA.
AC L5KM29;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Protein unc-13 like protein D {ECO:0000313|EMBL:ELK12357.1};
GN ORFNames=PAL_GLEAN10014714 {ECO:0000313|EMBL:ELK12357.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12357.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB030661; ELK12357.1; -; Genomic_DNA.
DR RefSeq; XP_006912275.1; XM_006912213.2.
DR RefSeq; XP_015445263.1; XM_015589777.1.
DR AlphaFoldDB; L5KM29; -.
DR STRING; 9402.L5KM29; -.
DR GeneID; 102897275; -.
DR CTD; 201294; -.
DR eggNOG; KOG1328; Eukaryota.
DR InParanoid; L5KM29; -.
DR OrthoDB; 3059697at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd08676; C2A_Munc13-like; 1.
DR CDD; cd04009; C2B_Munc13-like; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR PANTHER; PTHR45999:SF3; PROTEIN UNC-13 HOMOLOG D; 1.
DR PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 92..239
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 558..678
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 789..896
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 911..1036
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 1091 AA; 123192 MW; C73BEBAA1D08A616 CRC64;
MATPLSHSQR RPPLLRQAIK IRRRRVRDLQ GPLPHTAQEI EAPSHHFSPE ERALLYEEAL
YTVLHRLGKP EPGHVSEASE LLRYLQEAFH VEPEEHQRML RQVQALEKPI FCLKATVKQA
KGILGKDVSG FSDPYCLLGI EQGVGTLEGS PGSRRRQKAV VKHTIPEEQT HRTQVISQTL
NPVWDETFIL EFEDIRNSSF HLDMWDLDTV ESVRQKLGEL TDLHGLRRIF KEARKDKGQD
DFLGNVVLRL QDLRCREDQW YPLEPCTETY PDRGQCHLQF QLIHKRRATG ASRSQPSYTV
HLHLLQQLVS HEVTQHQAGS TSWDGLLSPQ AATILFLHAT QKDLSDFHQS MAQWLAYSRV
YQSLEFPSSC LLHPITSIEY QWIQGRLKAE QMEELATSFS SLLAYGLSLI RRFRSVFPLS
VSDSPARLQS LLRVLVQMCK MKAFRELCPD SGPLPHLVTE ALRAGTVEWF HLKQQHHQPM
VQGMLEAGKA LLSLVQDIIG DLHQCQRTWN KIFHNALKID LFAMAFLELQ WLVAKRVQDH
TAAALRGLVS PEMGESLFQL YIILKELCQL GPAPSERDGV LALDGFHRWF QPAIPSWLQK
TYSVALARVQ RAVQMDKLVP LGELTKHSTS AVDLSTCFAQ ISHTARQLDW PDPEEAFMIT
VKFVEDTCRL ALVYCSLIKA RARELSAGQK DQGQAANMLC VVVNDMEQLR LVIGRLPTQL
AWEALEQRVG AVLEQGQLQN TLHAQLQGAL AGLGHEIRTG VRTLAEQLEV GIAKHIQNLV
GVRESILPED AILPLMKFLE VELCYMNTNL VQENFSSLLT LLWTHTLEVM VEGATSQRSC
PLASSRLKIA LQNLEICFYA EGCGLQPEAL HTATFQALQR DLELQAASSR ELIQKYFCNR
IQQQAETTSE ELGAITVKAS YRASEQKLHV EVLSASSLLP LDSNGSSDPF VQLTLEPRHE
FPELAPRETQ KHKKDLHPLF DETFEFLVPA EPCQKDGACL LLTVLDHDTL GADDLEGEAF
LPLRSVLGLS GTEEPGEVPQ SRLPLTYPAP NGDPILQLLE SRKGDREAQV FVKLRRQRAK
QASQHAVRLG Q
//