ID   L5KNA6_PTEAL            Unreviewed;      1110 AA.
AC   L5KNA6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|EMBL:ELK13214.1};
GN   ORFNames=PAL_GLEAN10011210 {ECO:0000313|EMBL:ELK13214.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13214.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KB030625; ELK13214.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KNA6; -.
DR   STRING; 9402.L5KNA6; -.
DR   eggNOG; KOG3614; Eukaryota.
DR   InParanoid; L5KNA6; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELK13214.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        638..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        722..741
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        747..764
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        784..805
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        860..880
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          25..206
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          653..896
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   1110 AA;  124936 MW;  519711AB864BEAD6 CRC64;
     MERIVERVLV AAAQQRGGTK ADERRTEGAW ILTSALRVGL ARYVGQTVRD HSLASTSTKA
     RVVAIGIASL GRVLHRQLLD NAQEHSPVHY PTDDGAGQGP LCSLDNNHSH FILVEPGPPR
     KGDGQMELWL RLEKHISEQR TGYGGTWEDL TGPLSTGTGS IEIPVLCLLV NGDPSTLERI
     SRAVEHAAPW LVLAGSGGVA DVLAALVDQP HLLVPQLAEK QFKEKFPGKH FSREDIVHWT
     ELLQNIACHS HLLTVYDFEQ EGSEELDTVI LKALVKACKS HSQEAQDYLD ELKLAVAWDR
     VDIAKSEIFN GDVEWKSCDL EEAMMDALVS NKPEFVRLFV DHGASVADFL TYGRLQQLYR
     AVPPKSLLFD LLQRKHEEGR PAPQARGPPA FSLHDVSRVL KDFLHDACRG FYQAKWLLDL
     SQKSENPWRD LFLWAVLQSR HEMATYFWAM GQEGVAAALA ACKILREVSH LDVEAEAGHS
     TSQATYEQLA LGLFSECYSN SEDRAFALLV RRTRGWSRTT CLHLATEADT KAFFAHDGVQ
     AFLTRLWWGD MASGTSILRL LGAFLCPALL YTNLITFSEE VPLRTGLEDL QELDSLDTEK
     SLLCSPGSGV EEPAEAPRTQ GSRGPRVAFL LTRWRKFWGA PVTVFLGNVV MYFAFLFLFT
     YVLLVDFKPP PQGPSGPEVT LYFWVFTLVL EEIRQGFFTD EDVHLVKKFA LYVEDNWNKC
     DMVAIFLFVV GVICRMLSSA FEAGRAVLAI DFMVFTLRLI HIFAIHKQLG PKIIAVERMM
     KDVFFFLFFL SVWLVAYGVA TQALLHPHDS RLQWVFRRVL YRPYLQIFGQ IPLDEIDEAR
     VNCSTHPLLP EDSPACPNLY ANWLVILLLV TFLLVTNVLL MNLLIAMFSY TFQVVQGNAD
     MFWKFQRYHL IVEYQERPAL APPFILLSHL SLLLKRVFQK EAGQKRARLG EAPQPWASVW
     MGLGTGREAC WVGEQGCGWA PWEPDSCRAA SPERDLPEPL DQKMVIWEAV QKENYLSQRE
     KQRKGSAEEA LRKTAHRVDL LAKHLGGLRE QEKRIRGLES QVNYCTVLLS SMADTLAQGG
     ASPILLPIKR AVTAPSHLPL LLGSLRQQRL
//