ID L5KP58_PTEAL Unreviewed; 818 AA.
AC L5KP58;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Zinc finger protein 180 {ECO:0000313|EMBL:ELK12721.1};
GN ORFNames=PAL_GLEAN10003988 {ECO:0000313|EMBL:ELK12721.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12721.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB030659; ELK12721.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KP58; -.
DR STRING; 9402.L5KP58; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; L5KP58; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 13.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393:SF15; IP01201P-RELATED; 1.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 199..274
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 479..506
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 507..534
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 535..562
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 563..590
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 591..618
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 619..646
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 647..674
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 675..702
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 703..730
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 731..758
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 759..786
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 787..814
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 104..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 92915 MW; 14B841161B66E4DB CRC64;
MELWADSRTL VIHGLWRDDM GPCECEGIYN CAAFNPLSHP ARSALVLARV VGLQLSLSGG
AIAGIAVRIL TLIALSTGLG CFLQIRNARW PSKEAAEDPI YEATAPTSEG KLAAEPSSKG
MPRHGQPKYN KSVRAKHGPA WVSGPEQGDM RSMLGVTMHP GVACHGLSRF ESSLLPQEII
IKVEREDAGS LAVPSQEGVN FKIVTVDFTR EEERTLKHVQ RTLDRGVILE NHKDLVSWDS
ATAFERREST SKQSIFDDEP PCGVKTERLT RDDPWLSSCE EVWVCKDRLE RQQEKQERLL
KKVAFTQKNA VTHERVCKSD EVEEKNGLNS SLLSPQMIPI RNHFHKCASH VKKLHRNSVV
NSHEMINDSE KLYENNDCRN PPQSVHFIQF TRTQTEDKSY GFSNNIQSFS HRTPLNMHEK
IHARGKPFDF KECGQALNHS VSHSEQQGIP VEKSQYKYSK TSQSSSLVQN MRNSEEKPFE
CNQCGKSFSW SSHLVAHQRT HTGEKPYECN ECGKSFSRSS HLVSHQRTHT GEKPYRCNQC
GKSFSQSYVL VVHQRTHTGE KPYECNQCGK SFRQSYKLIA HQRTHTGEKP YECNQCGKSF
IQSYKLIAHQ RIHTGEKPYE CNQCGKSFSQ SYKLVAHQRT HTGEKPFECN QCGKSFSWSS
QLVAHQRTHT GEKPYECNEC GKSFNRSSHL VMHQRTHTGE KPYECNQCGK SFSQSYVLVV
HQRTHTGEKP YECNQCGKSF RQSSCLTQHQ RTHTGEKPYE CSQCGKTFSL SARLIVHQRT
HTGEKPFTCH QCGKAFINSS KLIRHQATHT EEKPYECN
//
