ID L5KPD5_PTEAL Unreviewed; 1142 AA.
AC L5KPD5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Sodium channel protein type 5 subunit alpha {ECO:0000313|EMBL:ELK13649.1};
GN ORFNames=PAL_GLEAN10001279 {ECO:0000313|EMBL:ELK13649.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13649.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030621; ELK13649.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KPD5; -.
DR STRING; 9402.L5KPD5; -.
DR eggNOG; KOG2301; Eukaryota.
DR InParanoid; L5KPD5; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|EMBL:ELK13649.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..435
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 521..680
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 731..960
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 968..1091
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT REGION 32..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 426..464
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 493..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 128353 MW; 1BFC9072FD2A205E CRC64;
MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGLATSQ ESRDGLPEEE APRPQLDLQA
SKKLPDLYGN PPRELLGEPL EDLDPYYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV
RRAAVKILVH SYPLQHGFLD SGSTLFSMLI MCTILTNCVF MAQHDPPPWT KYVEYTFTAI
YTFESLVKIL ARGFCLHAFT FLRDPWNWLD FSVIVMAYTT EFVDLGNVSA LRTFRVLRAL
KTISVISGLK TIVGALIQSV KKLADVMVLT VFCLSVFALI GLQLFMGNLR HKCVRNFTEL
NGTNGSVEAD GLVWDSLDLY LNDPENYLLK NGTSDVLLCG NSSDAGTCPE GYRCLKAGEN
PDHGYTSFDS FAWAFLALFR LMTQDCWERL YQQTLRSAGK IYMIFFMLVI FLGSFYLVNL
ILAVVAMAYE EQNQATIAET EEKEKRFQEA MEMLKKEHEA LTIRGVDTVS RSSLEMSPLA
LVTGRERRSK RRKRMSSGTE ECGDERFPKS DSEDGLRAMN RLSLTHGLSR TSMKPRSSRG
SIFTFRRRDL GSETDFADDE NSTAGDSESH RTSLLVPWPL RRPSAQAQPS PGTSGLGHAL
NGKRNSTVDC NGVVSLLGAG DPEATSPGSH LLRPMMLERP PDTTTPSEEA GRPQMLTPQA
PCVDGFEGPR ERQRALSAVS VLTSALEELE ESHRKCPPCW NRFAQRYLIW ECCPLWISIK
QKVKFMVMDP FADLTITMCI VLNTLFMALE HYNMTTEFEE MLQVGNLVFT GIFTAEMTFK
IIALDPYYYF QQGWNIFDSI IVILSLMELG LSRMGNLSVL RSFRLLRVFK LAKSWPTLNT
LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG MQLFGKNYSE LRHRISDSGL LPRWHMMDFF
HAFLIIFRIL CGEWIETMWD CMEVSGQSLC LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD
NLTAPDEDGE MNNLQLALAR IQRGLRFLKR TTWDFCCGLL QRRPQKPVVL ATRGQLPNCI
ATSSSPPPPE TEKVPPARKE TRFEESKHPG RGTPGDPEPV CVPIAVAESD TDDQEEDEEN
SLGTEEESSK QVCSTYLYRP QDLTVHGTWP HSEQLPLPDC DSRAGMSWKT GHAPTASLAE
RC
//
