ID   L5KPR3_PTEAL            Unreviewed;       964 AA.
AC   L5KPR3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Patched domain-containing protein 1 {ECO:0000313|EMBL:ELK12891.1};
GN   ORFNames=PAL_GLEAN10010536 {ECO:0000313|EMBL:ELK12891.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12891.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; KB030639; ELK12891.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KPR3; -.
DR   STRING; 9402.L5KPR3; -.
DR   eggNOG; KOG1934; Eukaryota.
DR   InParanoid; L5KPR3; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF36; PATCHED DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        347..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        575..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        776..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        801..821
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        833..854
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        866..891
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        903..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          344..503
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   964 AA;  109345 MW;  618A9CC6650B2EE3 CRC64;
     MECSFYSRPF KKGWIVSGTN DTAAAVVGNG SQVTLPNPKR KPHRSEDGVK MAMVLTEEEE
     VAAGQSTSVA PTLIFGSFSF AMDGPRGLER ATKHAKLYLH PVFFASAPVL ISILLGASFS
     RYQVEESVEH LLAPQHSLAK IERNLVNSLF PVNRSKHRLY SDLQTPGRYG RVIVTSFQKA
     NMLDQHHTDL ILKLHAAVTR IQVPRPGFNY TFAHICILNN DKTCIVDDIV HVLEELKNAR
     ATNRTNFAIT YPITHLKDGR AVYNGHQLGG VTVHSKDRVK SAEAVQLTYY LQSINSLNDM
     VAERWESSFC DTVRLFQKSN SKVKMYPYTS SSLREDFQKT SRVSERYLVT SLILVVTMAI
     LCCSMQDCVR SKPWLGLLGL VTISLATLTA AGIINLTGGK YNSTFLGVPF VMLGHGLYGT
     FEMLSSWRKT REDQHVKERT AAVYADSMLS FSLTTAMYLV TFGIGASPFT NIEAARIFCC
     NSCIAIFFNY LYVLSFYGSS LVFTGYIENN YQHSIFCRKV PKPEALQEKP AWYRFLLTAR
     FSEDTTDGEE ANTYESHLLV CFLKRYYCDW ITNTYVKPFV VLFYLIYISF ALMGYLQVSE
     GSDLSNIVAT ATQTIEYTTA QQKYFSNYSP VIGFYIYESI EYWNTSVQED VLEYTKGFVR
     ISWFESYLNY LRKLNVSTGL PKKNFTDMLR NSFLKAPQFS HFQEDIIFSK KYNDEVDVVA
     SRMFLVAKTM ETNREELYDL LETLRRLSVT SKVKFIVFNP SFVYMDRYAS SLGAPLHNSC
     ISALFLLFFS AFLVADSLIN VWLTLTVVSV EFGVIGFMTL WKVELDCISV LCLIYGINYT
     IDNCAPLLST FVLGKDFTRT KWVKNALEVH GVAILQSYLC YIVGLIPLAA VPSNLTCTLF
     RCLFLIAFVT FFHCFAILPV ILTFLPPSKK KRKEKKNPEN REEIECVEMV DIDSTRVVDQ
     ITTV
//