ID L5KQU8_PTEAL Unreviewed; 650 AA.
AC L5KQU8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 {ECO:0000313|EMBL:ELK13620.1};
DE Flags: Fragment;
GN ORFNames=PAL_GLEAN10012879 {ECO:0000313|EMBL:ELK13620.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13620.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; KB030623; ELK13620.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KQU8; -.
DR STRING; 9402.L5KQU8; -.
DR MEROPS; M28.975; -.
DR eggNOG; KOG2195; Eukaryota.
DR InParanoid; L5KQU8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03874; M28_PMSA_TfR_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF32; INACTIVE N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 286..450
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELK13620.1"
SQ SEQUENCE 650 AA; 72467 MW; FAED243CAFA6AE1B CRC64;
SYRNLVQLYT SEDDTEISKK IETQWTSLGL EDIQFVNYSV LLNLPGPSPS SVTLSSSGQC
FHPNGQPCSE EARKRNSQDL LYSYAAYSAK GTLEAEVIDV SYGNADDLKR IKKIKNVTNQ
IALLKLGKLP LLYKLLARGM RDGLIYFKKI NYGMNLITRM QKAVIDLKLS LLEKAGFGGV
LLYIDPCDLP KTANLSYDTF MVSLNPGGDP STPGYPSVDG SFRQNRPNLT SLLVQPISAS
LVAKLISPQK DRTRKGVCSP LELPNNEGRI VNMQVQTVTK FKTVTNVVGY LKGLTSPDRY
IIVGSHHHTA YSYSGQEWAS STAIITAFIQ ALMLRVKRGW RPDRSIVFCS WGGTAFGNIG
SYEWGEDFKK VLQRNAVAYV SLHSPIRGNS SLYSVASPSL QQLVAEKNNF NCSRRAQCPK
TNVSSVQIQG DSEYFINHLG VPTVQFAYED IKALQGPSFL SEALFPKHAT KIEEMDPFFT
LHETITKLSG EVILQIANEP VLPFNALDIA IEVQNSLKGD QPNTHQLLAL ASRLRESAEL
FQSDEMRPAN DPKERVPIRV RMLNDILQDM EKSFLVQQVP PGFYRNILYH LDKKTSQFSI
LLEAWEHCKT LASNETLQEA LSEVLHSINS AQVYFKAGLD VFDSVLVGKN
//
