ID   L5KRH1_PTEAL            Unreviewed;       742 AA.
AC   L5KRH1;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=N-acetylated-alpha-linked acidic dipeptidase-like protein {ECO:0000313|EMBL:ELK13368.1};
GN   ORFNames=PAL_GLEAN10011396 {ECO:0000313|EMBL:ELK13368.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13368.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC       protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; KB030625; ELK13368.1; -; Genomic_DNA.
DR   RefSeq; XP_006911188.1; XM_006911126.1.
DR   AlphaFoldDB; L5KRH1; -.
DR   STRING; 9402.L5KRH1; -.
DR   MEROPS; M28.011; -.
DR   GeneID; 102893898; -.
DR   KEGG; pale:102893898; -.
DR   CTD; 10004; -.
DR   eggNOG; KOG2195; Eukaryota.
DR   InParanoid; L5KRH1; -.
DR   OrthoDB; 2428249at2759; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          166..250
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          350..558
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          618..737
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
SQ   SEQUENCE   742 AA;  80471 MW;  BE987CD81ECDB52A CRC64;
     MKWVKVLGGV VGVAALLGLG IILGHFAIPK GADPLAPSVS QDLDLEILET VMGQLDASRI
     RENLRELSRE PHLASSPRDE ALVQLLLQRW RDPESGLDSA GTSTYEVLLS FPSQEQPNRV
     AVVAPTGDIL FSCRQSEENV TEEQAGPDVV SPYAAYAPSG TPQGLLVYAN WGMEEDFEEL
     QTQGIELKGT IALTRYGGIG RGAKAVNAAK YQVAGVLVYT DPADINDGHS LPNETFPHSW
     YLPPSGVERG SYYEYFGDPL TPYLPANPSS FRLDPTTASG FPPIPTQPIG FEDAKVLLCN
     LQGTSAPAAW QGALGCDYKL GPGFQPDGAF ASSQVNLSIH NSLELRNSSN VLGIIRGAVE
     PDRYVMYGNH RDSWVHGAVD PSSGTAVLLE ISRVLGTLLK KGTWRPRRSV VFASWGAEEF
     GLIGSTEFTE EFFSKLQERT VAYINVDISV FANATLRVQG TPPVQSVVFS AAKQIPAPDP
     SRLSIYDNWI RYFNRSSPVY GLVPRLGSLG AGSDYAPFIH FLGISSMDIA YTYDQSKTSA
     RIYPTYHTAF DTFSYVDKFV DPGFGSHLAV AQTAGNVLLR LSDSLFLPLN VSDYSETLRS
     FLQAAQQDLG ALLEQHSISL GPLVTAVEKF EEASIALGQN ISALQKANPN PLQVRMLNDQ
     LMLLERTFLN PRAFPEELYY SHVLWAPRTG SVATFPGLAN ACSRAMNTSL GSAAWAEVQR
     QLSIVVAALE GAAATLRPVD DL
//