ID L5KRV9_PTEAL Unreviewed; 432 AA.
AC L5KRV9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN ORFNames=PAL_GLEAN10004257 {ECO:0000313|EMBL:ELK14184.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14184.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KB030578; ELK14184.1; -; Genomic_DNA.
DR RefSeq; XP_006910202.1; XM_006910140.1.
DR AlphaFoldDB; L5KRV9; -.
DR STRING; 9402.L5KRV9; -.
DR GeneID; 102895484; -.
DR KEGG; pale:102895484; -.
DR CTD; 2670; -.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR InParanoid; L5KRV9; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 69..377
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 73..221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 268..348
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 432 AA; 49968 MW; 88715AEF0D965D57 CRC64;
MERRRVTSAA RRSYVSSSEM VLGALTPSRR LGAGTRLSLA RMPPPLPARV DFSLAGALNA
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
RELRLRLDQL TANSARLEVE RDNLAQDLGT LRQKLQDETN LRLEAENNLA TYRQEADEAT
LARLDLERKI ESLEDEIRFL RKIHEEEMRE IQEQLARQQV HVELDVAKPD LTAALREIRT
QYEAVASSNM HEAEEWYRSK FADLTDAAAR NTELLRQAKH EANDYRRQLQ ALTCDLESLR
GTNESLERQM REQEERHARE VASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNIKLALD
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
IKESKQEHKD VM
//
